| Effect of the nonionic surfactant poloxamer 338 on the fate and deposition of polystyrene microspheres following intravenous administration. | |
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MedLine Citation:
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PMID: 6631702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood clearance and organ deposition of polystyrene microspheres in the rabbit following intravenous injection has been investigated using the technique of gamma scintigraphy, blood and organ level measurements, and histology. Uncoated microspheres of 1.27-microns diameter were cleared rapidly from the blood and were taken up primarily by the reticuloendothelial system in the liver. Coating of the microspheres with the nonionic surface-active agent poloxamer 338 reduced the uptake in the liver and gave a corresponding increase in the lungs. |
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Authors:
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S L Illum; S S Davis |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 72 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1086-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Microspheres* Particle Size Poloxalene* Polyethylene Glycols* Polystyrenes / administration & dosage Rabbits Time Factors Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Polyethylene Glycols; 0/Polystyrenes; 9003-11-6/Poloxalene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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