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Effect of non-surgical periodontal therapy on interleukin-29 levels in gingival crevicular fluid of chronic periodontitis and aggressive periodontitis patients.
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MedLine Citation:
PMID:  23151616     Owner:  NLM     Status:  MEDLINE    
Recently discovered interleukin 29 (IL-29) has antiviral properties and its production is induced by herpes viruses. This study was aimed at analyzing the effect of non-surgical periodontal treatment on IL-29 levels in gingival crevicular fluid (GCF) of chronic and aggressive periodontitis patients. A total of 60 participants were divided into healthy group (group 1; n=20), chronic periodontitis group (group 2; n=20), and aggressive periodontitis group (group 3; n=20). GCF samples collected from each subject at baseline and 6-8 weeks after scaling and root planing were quantified for IL-29 levels using ELISA. The mean IL-29 concentration in GCF was found to be highest in group 3 (92.37 pg/μl). The mean IL-29 level in group 1 and group 2 was 36.88 pg/μl and 69.35 pg/μl respectively. After scaling and root planing, the mean concentration of IL-29 in GCF was increased to 85.99 pg/μl in group 2 and to 114.64 pg/μl in group 3. Results of the present study indicate that antiviral IL-29 level was highest in GCF of aggressive periodontitis patients and least in subjects with healthy periodontium, while that of chronic periodontitis lying in between. After non-surgical periodontal therapy, IL-29 levels increased both in chronic and aggressive periodontitis patients and deserve further investigation as a potential therapeutic agent in treating periodontitis.
B M Shivaprasad; A R Pradeep
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Disease markers     Volume:  34     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2013  
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-05-28     Revised Date:  2013-12-30    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Case-Control Studies
Chronic Periodontitis / metabolism*,  therapy
Dental Scaling
Gingival Crevicular Fluid / metabolism*
Interleukins / metabolism*
Root Planing*
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/IL29 protein, human; 0/Interleukins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2013 Hindawi Publishing Corporation.
Received Day: 12 Month: 11 Year: 2012
Accepted Day: 12 Month: 11 Year: 2012
Print publication date: Year: 2013
Electronic publication date: Day: 17 Month: 12 Year: 2012
Volume: 34 Issue: 1
First Page: 1 Last Page: 7
PubMed Id: 23151616
ID: 3809981
Article Id: 620964
DOI: 10.3233/DMA-2012-120944

Effect of Non-Surgical Periodontal Therapy on Interleukin-29 Levels in Gingival Crevicular Fluid of Chronic Periodontitis and Aggressive Periodontitis Patients
B. M. Shivaprasad12
A. R. Pradeep1*
1Department of PeriodonticsGovernment Dental CollegeHospital and Research InstituteBangaloreIndia
2Department of PeriodonticsRajarajeshwari Dental College and HospitalBangaloreIndia
Correspondence: *A. R. Pradeep:

Article Categories:
  • Other

Keywords: Interleukin 29, interferon lambda, chronic periodontitis, aggressive periodontitis.

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