Effect of non-steroid anti-inflammatory drugs in experimental myocardial infarction in rats. | |
MedLine Citation:
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PMID: 7202524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four non-steroid anti-inflammatory drugs, sulfinpyrazone, acetylsalicylic acid, sodium salicylate and indomethacin were tested in the acute phase of experimental myocardial infarction in conscious rats. A single oral dose was administered, then 1 h later the occlusion of the left anterior descending coronary artery was made by using a previously implanted silk loop. It was found that each drug markedly increased the survival rate, reduced the occurrence of ventricular fibrillation and tachycardia, and delayed the appearance and shortened the duration of arrhythmias. |
Authors:
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I Leprán; M Koltai; L Szekeres |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 69 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1981-05-26 Completed Date: 1981-05-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 235-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / therapeutic use* Aspirin / therapeutic use Coronary Vessels / physiology Indomethacin / therapeutic use Male Myocardial Infarction / drug therapy* Rats Salicylates / therapeutic use Sulfinpyrazone / therapeutic use |
Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Salicylates; 50-78-2/Aspirin; 53-86-1/Indomethacin; 57-96-5/Sulfinpyrazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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