Document Detail

Effect of non-steroid anti-inflammatory drugs in experimental myocardial infarction in rats.
MedLine Citation:
PMID:  7202524     Owner:  NLM     Status:  MEDLINE    
Four non-steroid anti-inflammatory drugs, sulfinpyrazone, acetylsalicylic acid, sodium salicylate and indomethacin were tested in the acute phase of experimental myocardial infarction in conscious rats. A single oral dose was administered, then 1 h later the occlusion of the left anterior descending coronary artery was made by using a previously implanted silk loop. It was found that each drug markedly increased the survival rate, reduced the occurrence of ventricular fibrillation and tachycardia, and delayed the appearance and shortened the duration of arrhythmias.
I Leprán; M Koltai; L Szekeres
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  69     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Aspirin / therapeutic use
Coronary Vessels / physiology
Indomethacin / therapeutic use
Myocardial Infarction / drug therapy*
Salicylates / therapeutic use
Sulfinpyrazone / therapeutic use
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Salicylates; 50-78-2/Aspirin; 53-86-1/Indomethacin; 57-96-5/Sulfinpyrazone

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