| Effect of non-selective gamma-aminobutyric acid receptor stimulation on motor function of the lower oesophageal sphincter and gastro-oesophageal reflux in healthy human subjects. | |
| | |
MedLine Citation:
|
PMID: 14510743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Transient lower oesophageal sphincter relaxation and low lower oesophageal sphincter pressure are the main mechanisms of reflux. It has recently been shown that the stimulation of gamma-aminobutyric acid type B (GABAB) receptors by baclofen decreases the rate of transient lower oesophageal sphincter relaxation and increases the lower oesophageal sphincter pressure in healthy humans. Valproic acid increases synaptosomal GABA concentrations, thus affecting all types of GABA receptors. AIM: To evaluate the effect of valproic acid on transient lower oesophageal sphincter relaxation, lower oesophageal sphincter pressure and gastro-oesophageal reflux. METHODS: Thirteen healthy subjects underwent 2-h post-prandial oesophageal motility and pH monitoring on two separate occasions after the oral administration of 1 g valproic acid or placebo. RESULTS: Valproic acid increased the lower oesophageal sphincter pressure by 41% (14.0 +/- 2.1 mmHg vs. 9.9 +/- 2.0 mmHg after placebo, P<0.02), but did not affect the rate of transient lower oesophageal sphincter relaxation (7.9 +/- 1.0/h vs. 8.2 +/- 0.9/h after placebo), the number of reflux episodes or gastro-oesophageal reflux. CONCLUSIONS: Non-selective GABA receptor stimulation may be beneficial to reflux patients with low lower oesophageal sphincter pressure, but exerts a different modulation of transient lower oesophageal sphincter relaxation than the selective stimulation of GABAB receptors. |
| | |
Authors:
|
P Cantù; S Carmagnola; D Savojardo; M Allocca; R Penagini |
Related Documents
:
|
8200263 - Biliary motility. changes in detailed characteristics correlated to duodenal migrating ... 499713 - Traumatic constipation. 17376303 - Pre-clinical atherosclerosis evaluated by carotid artery intima-media thickness and the... |
Publication Detail:
|
Type: Clinical Trial; Evaluation Studies; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Alimentary pharmacology & therapeutics Volume: 18 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2003 Oct |
Date Detail:
|
Created Date: 2003-09-26 Completed Date: 2004-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
|
Languages: eng Pagination: 699-704 Citation Subset: IM |
Affiliation:
|
Cattedra di Gastroenterologia, Dipartimento di Scienze Mediche, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Deglutition / drug effects Esophagogastric Junction / drug effects*, physiology Female GABA Agents / pharmacology* Gastroesophageal Reflux / drug therapy*, physiopathology Gastrointestinal Motility / drug effects Humans Hydrogen-Ion Concentration Male Manometry Middle Aged Muscle Relaxation / drug effects Receptors, GABA / drug effects* Valproic Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/GABA Agents; 0/Receptors, GABA; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of oxidative DNA damage in oesophageal biopsies of patients with reflux symptoms and norma...
Next Document: Oral esomeprazole vs. intravenous pantoprazole: a comparison of the effect on intragastric pH in hea...