Document Detail

Effect of non-aromatizable androgens on testicular and accessory gland functions in rhesus monkeys (Macaca mulatta).
MedLine Citation:
PMID:  2374134     Owner:  NLM     Status:  MEDLINE    
Adult male rhesus monkeys were injected intramuscularly 100 micrograms, 1000 micrograms 5 alpha-androstane-3 alpha, 17 beta-diol or 100 micrograms dihydrotestosterone (DHT) per day for 70 days. A decrease in seminiferous tubular diameter was seen in treated animals. Androstanediol treatment disrupted spermatogenesis in most tubules. Sperm motility decreased within 40 days and by Day 70 non-motile spermatozoa were seen in 2 animals of each group treated with androstanediol. DHT treatment also decreased sperm motility progressively from Day 40. Both androgens caused retention of the cytoplasmic droplet and an increase in coiling of the tail of spermatozoa. Seminal fructose was decreased by Day 40 (1000 micrograms androstanediol) or Day 70 (100 micrograms androstanediol and 100 micrograms DHT). Seminal glycerophosphocholine (GPC) and acid phosphatase levels decreased by Day 70 in all treatment groups. Both steroids decreased circulating concentrations of testosterone without altering FSH or oestradiol values.
P R Ramakrishnan; J Kaur; M Rajalakshmi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  89     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-30     Completed Date:  1990-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Androgens / pharmacology*
Androstane-3,17-diol / pharmacology
Fructose / metabolism
Glycerylphosphorylcholine / metabolism
Macaca mulatta
Semen / metabolism
Seminiferous Tubules / drug effects
Sperm Motility / drug effects
Spermatogenesis / drug effects*
Spermatozoa / drug effects
Testis / drug effects,  physiology*
Testosterone / blood
Reg. No./Substance:
0/Androgens; 25126-76-5/Androstane-3,17-diol; 30237-26-4/Fructose; 563-24-6/Glycerylphosphorylcholine; 58-22-0/Testosterone

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