Document Detail


Effect of noise exposure on gap detection in rats.
MedLine Citation:
PMID:  15668039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intense (110-120 dB) noise exposure (broadband noise for one hour) on temporal resolution was estimated in rats by measuring the behavioural gap detection threshold (GDT). Changes in GDT after 120 dB noise exposure were compared with changes in the threshold and amplitude of middle latency responses (MLR) recorded in response to tone stimuli. GDT values increased from 1.6 to 4.3 or 7.8 ms after exposure to 110 or 115 dB SPL, respectively; GDT recovered to pre-exposure values in 3-7 days. Three main types of noise-induced changes were observed after 120 dB SPL exposure: (I) GDT changes similar to those following noise exposure to 115 dB SPL and maximal hearing threshold shifts (TSs) at high frequencies of about 45 dB; (II) more pronounced changes in GDT (up to 60 ms) with maximal hearing threshold shifts of about 65 dB and (III) a lack of reliable responses to gap during the first weeks post-exposure with maximal hearing threshold shifts of about 80 dB. An increased GDT was present two months after noise exposure in animals with types II and III post-exposure changes; enhanced MLR amplitudes were also found in most of these in the first post-exposure week. The pronounced deficit in gap detection in some rats after 120 dB SPL noise exposure may signal the presence of a noise-induced tinnitus.
Authors:
N Rybalko; J Syka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  200     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
Affiliation:
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnská 1083, 142 20 Prague 4, Czech Republic. rybalko@biomed.cas.cz
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Perception / physiology*
Behavior, Animal
Female
Hearing Loss, Noise-Induced / physiopathology
Noise / adverse effects*
Rats
Rats, Long-Evans
Tinnitus / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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