Document Detail

Effect of nitrous oxide on propofol requirement during target-controlled infusion for oocyte retrieval.
MedLine Citation:
PMID:  17125991     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oocyte (egg) retrieval for in-vitro fertilization is a relatively short procedure, usually performed as an outpatient. Propofol is a suitable anesthetic agent. Target-controlled infusion is a recently developed system that aids rapid recovery from propofol anesthesia. This study sought to determine the target concentration of propofol required to prevent movement in 50% (Cp50) and 95% (Cp95) of women during oocyte retrieval, and investigated whether supplemental nitrous oxide (N2O) modified the Cp50 and Cp95. METHODS: Forty-seven women scheduled for oocyte retrieval were randomly selected to receive either O2-air mixture (control group; n = 23) or 50% O2-N2O mixture (Nitrous oxide group; n = 24). Propofol was infused using a target-controlled infusion system with the concentration determined by up-down sequential allocation using 0.5 microg/mL step size. Transvaginal oocyte retrieval was performed after reaching target blood concentration. Patient responses to oocyte retrieval were noted as either no movement or movement. RESULTS: Using target-controlled infusion the Cp50 was 4.1 microg/mL in the control group and 3.3 microg/mL in the nitrous oxide group. Calculated Cp95 values were 4.0 microg/mL and 5.1 microg/mL with and without 50% nitrous oxide respectively. CONCLUSIONS: The Cp50 value for target-controlled infusion propofol during oocyte retrieval was significantly reduced by a factor of 1.24 (95% CI 1.07-1.44) with the use of 50% nitrous oxide.
F Handa-Tsutsui; M Kodaka
Publication Detail:
Type:  Journal Article     Date:  2006-11-27
Journal Detail:
Title:  International journal of obstetric anesthesia     Volume:  16     ISSN:  0959-289X     ISO Abbreviation:  Int J Obstet Anesth     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-20     Completed Date:  2007-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200430     Medline TA:  Int J Obstet Anesth     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
Department of Anesthesiology, Saitama Medical Center, Kawagoe, Saitama, Japan.
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MeSH Terms
Ambulatory Surgical Procedures
Anesthesia, Intravenous / methods
Anesthetics, Inhalation / pharmacology*
Anesthetics, Intravenous / administration & dosage*
Dose-Response Relationship, Drug
Fertilization in Vitro
Monitoring, Intraoperative
Movement / drug effects
Nitrous Oxide / pharmacology*
Propofol / administration & dosage*
Regression Analysis
Tissue and Organ Harvesting
Ultrasonography, Interventional / methods
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 10024-97-2/Nitrous Oxide; 2078-54-8/Propofol

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