Document Detail

Effect of nitrous oxide on the cardiovascular system and coronary circulation of the dog.
MedLine Citation:
PMID:  518795     Owner:  NLM     Status:  MEDLINE    
A comparison was made in seven dogs anaesthetized with pentobarbitone of cardiovascular measurements during ventilation with 65-70% nitrous oxide in oxygen and ventilation with 65-70% nitrogen in oxygen. The substitution of nitrous oxide for nitrogen was found to be associated, after 15 min, with a significant decrease in cardiac output and significant increases in right atrial and left ventricular end-diastolic pressure and systemic vascular resistance. There was no significant change in mean coronary artery flow, coronary vascular resistance or myocardial oxygen consumption.
J Thorburn; G Smith; J P Vance; D M Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  51     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  937-42     Citation Subset:  IM    
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MeSH Terms
Coronary Circulation / drug effects*
Depression, Chemical
Hemodynamics / drug effects*
Myocardial Contraction / drug effects
Myocardium / metabolism
Nitrous Oxide / pharmacology*
Oxygen Consumption / drug effects
Reg. No./Substance:
10024-97-2/Nitrous Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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