Document Detail


Effect of nitroglycerin on ventricular fibrillation threshold of nonischemic myocardium.
MedLine Citation:
PMID:  821329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The threshold for ventricular fibrillation induced by a 200 msec train of pulses was measured during a control period and during an intravenous infusion of nitroglycerin in 14 nonischemic open chest dogs. Infusion of nitroglycerin in doses sufficient to reduce mean arterial blood pressure an average of 17 mm Hg was associated with a rise in ventricular fibrillation threshold from a control value of 24 +/- 3 (mean +/- 1 standard error of the mean) to 41 +/- 6 milliamperes (P less than 0.001). In a subgroup of six animals simultaneous infusions of nitroglycerin and phenylephrine abolished the hypotensive effect of nitroglycerin but did not significantly alter the rise in ventricular fibrillation threshold observed with nitroglycerin infusion alone. In five other animals mean arterial blood pressure was similarly reduced an average of 17 mm Hg by venous hemorrhage, but was associated with a lowering than a rise in ventricular fibrillation threshold from a prehemorrhage value of 28 +/- 6 to 15 +/- 2 milliamperes, (P less than 0.005). Thus, intravenously administered nitroglycerin raises ventricular fibrillation threshold in nonischemic canine myocardium independent of its hypotensive effects.
Authors:
N Dashkoff; J M Roland; P J Varghese; B Pitt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  38     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  184-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Blood Pressure / drug effects
Dogs
Dose-Response Relationship, Drug
Drug Therapy, Combination
Hemorrhage / drug therapy
Nitroglycerin / administration & dosage,  pharmacology*
Phenylephrine / pharmacology
Venous Pressure / drug effects
Ventricular Fibrillation / prevention & control*
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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