Document Detail

Effect of nitroglycerin ointment (Nitrong) on exercise tolerance and several circulatory parameters in patients with angina pectoris.
MedLine Citation:
PMID:  6411479     Owner:  NLM     Status:  MEDLINE    
Nine patients with coronary heart disease, 8 of whom were taking adrenergic beta-blockers, were tested by dynamic (bicycle) and isometric (sitting handgrip) exercise before and 2 and 6 h after application of nitroglycerin 30 mg in an ointment, or a matching placebo ointment, over 225 cm2 surface on the chest, in a double-blind, cross-over, single dose study. Exercise time until stopping from chest pain was significantly increased (by about 20%) by active ointment, and electrocardiographic ST-depression and chest pain intensity were significantly less pronounced during exercise both 2 and 6 h after application. During seated rest, active ointment also produced a significantly lower systolic blood pressure and a significantly higher heart rate at both 2 and 6 h, whereas during handgrip, significant differences from placebo were seen only at 2 h. All patients experienced headache for at least the 6 h of the study. At a given heart rate, ST-depression was less pronounced with active ointment than with placebo.
G Nyberg; V Panfilov
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  24     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  733-9     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / drug therapy,  physiopathology*
Hemodynamics / drug effects*
Isometric Contraction
Middle Aged
Nitroglycerin / administration & dosage*,  adverse effects
Physical Exertion
Reg. No./Substance:
0/Ointments; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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