Document Detail

Effect of nitric oxide synthase inhibition on regional blood flow during hyperthermia.
MedLine Citation:
PMID:  11070338     Owner:  NLM     Status:  Publisher    
The loss of compensatory splanchnic vasoconstriction during hyperthermia was assessed in rats after administration of either 0, 10, 30, or 100mg/kg N(w)-nitro-L-arginine methyl ester,L-NAME. Rectal temperature (T(re)), heart rate (HR), mean arterial blood pressure (MAP), breathing frequency (BF), and renal, mesenteric and caudal blood flows (Q(R), Q(M) and Q(C)) were measured until irreversible cardiovascular collapse occurred. HR, MAP and BF increased as T(re) rose to 42 degrees C, then fell as circulatory collapse occurred. As dose increased T(re) at collapse decreased. Q(M) decreased until a T(re) of 41.5-42 degrees C and then increased. Q(R) and Q(C) were unaffected by either hyperthermia orL-NAME. Inhibition of NO synthase did not prevent the circulatory collapse of heatstroke; the higher doses ofL-NAME may have exacerbated the onset of circulatory failure.
Sils; Szlyk-Modrow; Tartarini; Matthew; Francesconi
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Publication Detail:
Journal Detail:
Title:  Journal of thermal biology     Volume:  26     ISSN:  0306-4565     ISO Abbreviation:  J. Therm. Biol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2000-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600115     Medline TA:  J Therm Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-7     Citation Subset:  -    
Military Nutrition and Biochemistry Division, US Army Research Institute of Environmental Medicine, Kansas Street, 01760-5007, Natick, MA, USA
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