| Effect of nitric oxide synthase inhibition on the uterine vasculature of the late-pregnant ewe. | |
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MedLine Citation:
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PMID: 10329868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We studied the role of nitric oxide in the maintenance of uterine vascular tone during pregnancy. STUDY DESIGN: Late-pregnant ewes were instrumented with ultrasonographic flow probes on the left and right main uterine arteries. A catheter was passed retrogradely into 1 uterine artery from a tributary. In 14 animals nitric oxide synthase inhibitor (N omega-nitro-L-arginine methyl ester; L-NAME) was infused at 2 or 20 mg/kg during a 1-minute period into either the main left or right uterine artery. RESULTS: The nitric oxide synthase inhibitor (20 mg/kg), infused into 1 uterine artery, significantly decreased uterine blood flow (P <.001) bilaterally, increased (P <.05) mean arterial pressure, and decreased heart rate (P <.05). The compound (when infused at 2 mg/kg) also significantly (P <.05) decreased uterine blood flow in the artery ipsilateral to, but not contralateral to, the infusion, with no change in mean arterial pressure and a decrease (P <.05) in heart rate. CONCLUSION: During ovine pregnancy, endogenous nitric oxide production contributes to uterine vasodilatation. |
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Authors:
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S L Miller; G Jenkin; D W Walker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 180 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-06-18 Completed Date: 1999-06-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1138-45 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, Monash University, Clayton, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects Blood Flow Velocity / drug effects Blood Pressure / drug effects Enzyme Inhibitors / pharmacology* Female Gestational Age* Infusions, Intra-Arterial Kinetics NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide Synthase / antagonists & inhibitors* Pregnancy Sheep Uterus / blood supply* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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