Document Detail

Effect of nitric oxide on oxygenation and hemodynamics in infants after cardiac surgery.
MedLine Citation:
PMID:  9012899     Owner:  NLM     Status:  MEDLINE    
We evaluated the effect of nitric oxide (NO) on infants after congenital cardiac surgery. Inhaled NO was administered to 7 infants after congenital cardiac surgery. Inhaled NO concentration ranged from 2.5 to 10 parts per million (ppm). The respiratory index (RI = A-aDO2/PaO2) decreased from 7.4 +/- 2.5 to 4.7 +/- 3.1 in the right RI group (RI > or = 3, n = 4) 30 min after NO inhalation. After discontinuation of NO inhalation, RI increased to the preinhalation level. NO inhalation was restarted in 2 patients in the high RI group because of severe worsening of oxygenation. RI was not affected by starting or discontinuing of NO in the low RI group (RI < 3, n = 3). Systemic blood pressure did not significantly change in the 2 groups. Pulmonary arterial pressure (PAP) was measured in 4 patients, and it decreased by 21, 10, and 10%, respectively, 30 min after NO inhalation in 3 patients, but did not change in the remaining patient. After discontinuation of NO inhalation, PAP increased in all patients, and in 2 cases, PAP was higher than baseline value. NO inhalation is effective in improving oxygenation in infants with a high RI after cardiac surgery. However, careful monitoring of the respiratory and hemodynamic states is required after discontinuing NO inhalation.
K Sadao; S Masahiro; M Toshihiko; N Yasuaki; T Yusaku
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  21     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-17     Completed Date:  1997-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  14-6     Citation Subset:  IM    
Critical Care Medical Center, Wakayama Medical College, Japan.
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MeSH Terms
Administration, Inhalation
Blood Pressure / drug effects*
Cardiac Surgical Procedures / adverse effects*,  mortality
Heart Defects, Congenital / surgery*
Infant, Newborn
Nitric Oxide / administration & dosage,  pharmacology*,  therapeutic use
Oxygen Consumption / drug effects*
Postoperative Complications / prevention & control
Pulmonary Wedge Pressure / drug effects*
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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