| Effect of nitric oxide on oxygenation and hemodynamics in infants after cardiac surgery. | |
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MedLine Citation:
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PMID: 9012899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effect of nitric oxide (NO) on infants after congenital cardiac surgery. Inhaled NO was administered to 7 infants after congenital cardiac surgery. Inhaled NO concentration ranged from 2.5 to 10 parts per million (ppm). The respiratory index (RI = A-aDO2/PaO2) decreased from 7.4 +/- 2.5 to 4.7 +/- 3.1 in the right RI group (RI > or = 3, n = 4) 30 min after NO inhalation. After discontinuation of NO inhalation, RI increased to the preinhalation level. NO inhalation was restarted in 2 patients in the high RI group because of severe worsening of oxygenation. RI was not affected by starting or discontinuing of NO in the low RI group (RI < 3, n = 3). Systemic blood pressure did not significantly change in the 2 groups. Pulmonary arterial pressure (PAP) was measured in 4 patients, and it decreased by 21, 10, and 10%, respectively, 30 min after NO inhalation in 3 patients, but did not change in the remaining patient. After discontinuation of NO inhalation, PAP increased in all patients, and in 2 cases, PAP was higher than baseline value. NO inhalation is effective in improving oxygenation in infants with a high RI after cardiac surgery. However, careful monitoring of the respiratory and hemodynamic states is required after discontinuing NO inhalation. |
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Authors:
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K Sadao; S Masahiro; M Toshihiko; N Yasuaki; T Yusaku |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Artificial organs Volume: 21 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-17 Completed Date: 1997-04-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 14-6 Citation Subset: IM |
Affiliation:
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Critical Care Medical Center, Wakayama Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Blood Pressure / drug effects* Cardiac Surgical Procedures / adverse effects*, mortality Female Heart Defects, Congenital / surgery* Humans Infant Infant, Newborn Male Nitric Oxide / administration & dosage, pharmacology*, therapeutic use Oxygen Consumption / drug effects* Postoperative Complications / prevention & control Pulmonary Wedge Pressure / drug effects* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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