Document Detail

Effect of nifedipine, dilazep, dinitrates and propranolol on blood lactate accumulation during intensive graded exercise testing in healthy young subjects.
MedLine Citation:
PMID:  3221439     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to elucidate the effects of 4 different cardiovascular drugs on blood lactate levels during an intensive graded exercise test in 17 healthy male subjects. In acute studies, isosorbide dinitrate and nifedipine were used. In chronic studies, propranolol dihydrochloride and dilazep dihydrochloride were used. Oxygen uptake (VO2), heart rate, blood pressure and blood lactate were measured at rest and during the final minute of each exercise session. Hemodynamic measurements during submaximum exercise were influenced by all drugs except isosorbide dinitrate. VO2 during submaximum and maximum exercises remained unchanged by all drug treatments. Blood lactate levels at rest and during submaximum and maximum exercise also did not change significantly. Work load corresponding to blood lactate concentration of 4 mM (W4 mM) and the 1st and 2nd break points of lactic acid (WBPLA1 and WBPLA2) were almost the same in all treatments. It is concluded that the 3 criteria of blood lactate obtained during the graded exercise test are not affected by these drugs in healthy males.
H Tanaka; S Kumagai; M Shindo; T Yoshida; T Mutaguchi; Y Moriyama; T Hiroki; K Arakawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese heart journal     Volume:  29     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-03-15     Completed Date:  1989-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  617-30     Citation Subset:  IM    
Department of Exercise Physiology, School of Physical Education, Fukuoka University, Japan.
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular Agents / pharmacology*
Dilazep / pharmacology
Exercise Test*
Heart Rate / drug effects
Lactates / blood*
Lactic Acid
Nifedipine / pharmacology
Nitrates / pharmacology
Propranolol / pharmacology
Reg. No./Substance:
0/Cardiovascular Agents; 0/Lactates; 0/Nitrates; 21829-25-4/Nifedipine; 35898-87-4/Dilazep; 50-21-5/Lactic Acid; 525-66-6/Propranolol

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