| Effect of nicotine on the lower esophageal sphincter. Studies on the mechanism of action. | |
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MedLine Citation:
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PMID: 1150020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous administration of nicotine sulfate caused a dose-dependent reduction in the lower exophagel sphincter pressure in anesthetized opossums. The maximal reduction in pressure of 85.0 +/- 2.6% was observed with a dose of 50 mug per kg. The effect of 50 mug per kg was not antagonized by bilateral cervical vagotomy, atropine, propranolol or by catecholamine depletion with reserpine. The sphincter relaxation produced by 50 mug per kg of nicotine was antagonized during tachyphylaxis produced by a larger dose (4 mg per kg) of nicotine. Nicotine tachyphylaxis also blocked the vagal-stimulated relaxation of the sphincter. It is suggested that the main action of nicotine on the sphincter in intact animals is caused by its effect on the noncholinergic, nonadrenergic inhibitory neurons which lie in the vagal pathway to the lower esophageal sphincter. |
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Authors:
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S Rattan; R K Goyal |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 69 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-11-06 Completed Date: 1975-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 154-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Electric Stimulation Esophagogastric Junction / drug effects* Hexamethonium Compounds / pharmacology Injections, Intra-Arterial Injections, Intravenous Nicotine / administration & dosage, pharmacology* Opossums / physiology* Pressure Propranolol / pharmacology Reserpine / pharmacology Tachyphylaxis Vagotomy |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 50-55-5/Reserpine; 51-55-8/Atropine; 525-66-6/Propranolol; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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