Document Detail

Effect of nicorandil on exercise performance in patients with effort angina: a multicenter trial using a treadmill exercise test.
MedLine Citation:
PMID:  2447432     Owner:  NLM     Status:  MEDLINE    
The effects of a single oral dose (20 mg) of a new vasodilator, nicorandil, on exercise performance were assessed in 29 patients with stable effort angina using a symptom-limited treadmill exercise test. A single-blind, placebo-controlled, randomized, crossover design was employed. Compared with placebo, 20 mg of nicorandil significantly increased maximal exercise duration and time to 1 mm of ST-segment depression at 1, 3, and 6 h after administration. Systolic blood pressure was reduced both at rest and during exercise. Heart rate increase during exercise did not differ significantly compared with control, though resting heart rate was increased. The maximal pressure-rate product at peak exercise was increased in association with increased exercise time in about half of the patients, while it was unchanged or decreased in the others. It was suggested that nicorandil may act by either reducing myocardial oxygen demand and/or increasing myocardial oxygen supply.
K Kato; H Asanoi; C Wakabayashi; S Hosoda; A Shiina; K Hosono; A Kurita; K Seki; K Ishida; A Kuroiwa
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 8     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-02-02     Completed Date:  1988-02-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S98-103     Citation Subset:  IM    
Cardiovascular Institute, Tokyo, Japan.
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MeSH Terms
Angina Pectoris / physiopathology*
Blood Pressure / drug effects
Heart Rate / drug effects
Middle Aged
Niacinamide / analogs & derivatives*,  pharmacology
Physical Exertion / drug effects*
Random Allocation
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Vasodilator Agents; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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