Document Detail


Effect of nicorandil on exercise performance in patients with effort angina: a multicenter trial using a treadmill exercise test.
MedLine Citation:
PMID:  2447432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of a single oral dose (20 mg) of a new vasodilator, nicorandil, on exercise performance were assessed in 29 patients with stable effort angina using a symptom-limited treadmill exercise test. A single-blind, placebo-controlled, randomized, crossover design was employed. Compared with placebo, 20 mg of nicorandil significantly increased maximal exercise duration and time to 1 mm of ST-segment depression at 1, 3, and 6 h after administration. Systolic blood pressure was reduced both at rest and during exercise. Heart rate increase during exercise did not differ significantly compared with control, though resting heart rate was increased. The maximal pressure-rate product at peak exercise was increased in association with increased exercise time in about half of the patients, while it was unchanged or decreased in the others. It was suggested that nicorandil may act by either reducing myocardial oxygen demand and/or increasing myocardial oxygen supply.
Authors:
K Kato; H Asanoi; C Wakabayashi; S Hosoda; A Shiina; K Hosono; A Kurita; K Seki; K Ishida; A Kuroiwa
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 8     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-02-02     Completed Date:  1988-02-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S98-103     Citation Subset:  IM    
Affiliation:
Cardiovascular Institute, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / physiopathology*
Blood Pressure / drug effects
Electrocardiography
Female
Heart Rate / drug effects
Humans
Male
Middle Aged
Niacinamide / analogs & derivatives*,  pharmacology
Nicorandil
Physical Exertion / drug effects*
Random Allocation
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Examination of the direct effects of nicorandil, verapamil, propranolol, and nitroglycerin on the hy...
Next Document:  Altered adrenergic control in hypercholesterolemia.