Document Detail

Effect of nickel sulfate on cellular proliferation and Epstein-Barr virus antigen expression in lymphoblastoid cell lines.
MedLine Citation:
PMID:  3019516     Owner:  NLM     Status:  MEDLINE    
Nickel is found in high levels in the environment of the high-risk areas for nasopharyngeal carcinoma (NPC) of China. Epstein-Barr virus (EBV) is associated with NPC and the interaction of nickel and EBV may be a contributive cofactor to the development of NPC. The study of the in vitro effect of nickel sulfate on cell proliferation and EBV-antigen expression demonstrated that nickel increases cell proliferation of some EBV-positive lymphoblastoid cell lines and increases early antigen expression of Raji cells. Nickel exerted variable effects on viral capsid antigen (VCA): increasing VCA-positive cells in B95-8 cells while decreasing VCA in P3HR-1 cells. It is proposed that the uptake of nickel in NPC high-risk areas could be one of the factors responsible for cancer development in the nasopharynx in China.
Y T Wu; H L Luo; D R Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  32     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-30     Completed Date:  1986-10-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  171-9     Citation Subset:  IM    
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MeSH Terms
Antigens, Viral / analysis*
Capsid Proteins*
Cell Division / drug effects
Cell Line
Epstein-Barr Virus Nuclear Antigens
Herpesvirus 4, Human / immunology*
Lymphocytes / immunology
Nasopharyngeal Neoplasms / etiology
Nickel / toxicity*
Grant Support
Reg. No./Substance:
0/Antigens, Viral; 0/Capsid Proteins; 0/Epstein-Barr Virus Nuclear Antigens; 0/Epstein-Barr viral capsid antigen; 7440-02-0/Nickel; 7786-81-4/nickel sulfate

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