Document Detail


Effect of the new legislation and single-embryo transfer policy in Turkey on assisted reproduction outcomes: preliminary results.
MedLine Citation:
PMID:  21195669     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
New legislation concerning assisted reproduction treatments was introduced in Turkey in March 2010 in order to reduce the number of multiple pregnancies. This new legislation limits the number of embryos to be transferred to one under 35years of age in the first or second treatment cycles and to two in the third or further cycles or for 35 and older ages. The aim of this multicentre study was to investigate the effect of this new law on clinical pregnancy and multiple pregnancy rates. Outcomes were compared in equal periods of 2.5months before and after the new law, and further investigation was conducted for two different age groups: <35 and ⩾35. The clinical pregnancy rates decreased from 39.9 to 34.5% and multiple pregnancy rates decreased from 23.1 to 5.3% (P<0.001) for the overall population. The outcomes of the <35 age group and ⩾35 age group were also similar to that of the overall population. These results suggest that under the new legislation multiple pregnancy rates are significantly reduced without causing a significant decline in the pregnancy rates. Lay summary Multiple pregnancies are common and undesirable outcomes of assisted reproduction treatments. Single-embryo transfer policy is a successful way to reduce the number of multiple pregnancies, thus it is increasingly gaining acceptance throughout the world. Turkish government had an attempt to promote single-embryo transfer on 6 March 2010 via a new legislation. According to this new regulation, only one embryo transfer is permitted in the first and second treatment cycles of patients under 35, a maximum of two embryos can be transferred in the third or further cycles, and a maximum of two embryos can be transferred to patients aged ⩾35years. The aim of our multicentre study was to investigate the effect of this new law on clinical pregnancy and multiple pregnancy rates. Outcomes were compared in equal periods of 2.5months before and after the new law, and further investigation was conducted for two different age groups: <35 and ⩾35years. The pregnancy rates were decreased from 39.9 to 34.5% and multiple pregnancy rates were decreased from 23.1 to 5.3% (P<0.001) among all patients. The outcomes of the <35 age group and the ⩾35 age group were also similar to the overall patient group. These results suggest that the new legislation provides significantly low multiple pregnancy rates while not causing an important decline in the pregnancy rates.
Authors:
P Kutlu; O Atvar; O F Vanlioglu; U Kutlu; A Arici; S Yilmaz; E Yilmaz; N Delikara; F Bener; A Kamar; O Alpak; U Ozekici
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Publication Detail:
Type:  Journal Article     Date:  2010-10-31
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  22     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  208-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Medicana Camlica Hospital, Clinics of Fertility, Alemdag Cad, No. 85, Uskudar, Istanbul, Turkey.
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