Document Detail


Effect of neurotensin on regional intestinal blood flow in the dog.
MedLine Citation:
PMID:  7268217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of various doses of synthetic neurotensin on regional blood flow in different tissue layers of the stomach, small bowel, colon, pancreas, brain, kidneys, adrenal gland, and heart of six dogs was studied using an isotope microsphere technique. Infusion of high doses (20, 40 pmol/kg . min(-1)) of exogenous synthetic neurotensin caused an increase of blood flow in the "muscularis" of duodenum, jejunum, ileum, and colon. Neurotensin infused in a dose (2.5 pmol/kg . min(-1)) raising neurotensin plasma levels to concentrations comparable to those observed after a meal caused an increase of blood flow in the muscular layer in ileum. Our results suggest that one of the physiologic actions of neurotensin may be the regulation of blood flow in the muscular layer of the ileum.
Authors:
I Baća; U Mittmann; G E Feurle; M Haas; T Müller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  179     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1981  
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Digestive System / blood supply*
Dogs
Dose-Response Relationship, Drug
Gastric Acid / secretion
Gastrointestinal Motility / drug effects
Hemodynamics / drug effects
Intestinal Mucosa / blood supply
Neurotensin / pharmacology*
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
39379-15-2/Neurotensin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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