Document Detail

Effect of neurotensin on colorectal motor and sensory function in humans.
MedLine Citation:
PMID:  15043292     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Animal studies have shown that neurotensin stimulates colonic motility, but little is known on the effect on rectocolonic function in humans. This study was designed to investigate the effect of neurotensin on rectal and colonic motor and sensory function and colonic reflexes in humans. METHODS: Motor and sensory function of the descending colon and rectum were studied in eight healthy volunteers (5 females; age range, 20-58 years) by using a dual, computerized, rectocolonic, barostat assembly. Measurements were performed during placebo and neurotensin infusion (5 pmol/kg per minute), respectively. Compliance and reflex mechanisms were assessed in both rectum and descending colon. Symptom perception (urge and pain) was scored using Visual Analog Scales (0-10 cm). RESULTS: Neurotensin significantly (P < 0.05) increased rectal compliance (from 9 +/- 1.1 to 10.1 +/- 1.1 ml/mmHg) and colonic compliance (from 7.9 +/- 0.4 to 9 +/- 0.7 ml/mmHg) during stepwise distensions. Intensity of urge and pain perception during rectal distension was increased by neurotensin (P < 0.05). Sensations during colonic distensions were not altered by neurotensin. For colonic reflexes, during rectal distension the colonic bag volume increased significantly (P < 0.05), whereas during colonic distension rectal bag volume decreased significantly (P < 0.05). Neurotensin delayed the occurrence of these reflexes: they were present at significantly higher pressures compared to placebo (P < 0.05). CONCLUSIONS: We demonstrated the presence of both a rectocolonic inhibitory and a colorectal stimulatory reflex in healthy volunteers. Neurotensin increases compliance and modulates rectal but not colonic sensitivity. Colorectal and rectocolonic reflexes are impaired during infusion of neurotensin.
Patrick P J van der Veek; Elleke D C M Schots; Ad A M Masclee
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  47     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-04-02     Revised Date:  2005-09-01    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
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MeSH Terms
Colon / physiology*
Gastrointestinal Motility / drug effects*
Middle Aged
Neurotensin / pharmacology*
Pain Threshold*
Rectum / physiology*
Reg. No./Substance:
Comment In:
Dis Colon Rectum. 2005 Aug;48(8):1671-2   [PMID:  15937614 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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