Document Detail

Effect of neuropeptide Y on hemodynamics of the rabbit lung.
MedLine Citation:
PMID:  9475874     Owner:  NLM     Status:  MEDLINE    
We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10(-8) and 10(-7) M NPY increased pulmonary arterial pressure (Ppa) from 11.5 +/- 1.0 (SE) mmHg to, respectively, 16.4 +/- 1.5 and 26.0 +/- 3.8 mmHg (P < 0.05, n = 5 mmHg lungs), with 78 +/- 4% of the increase at 10(-7) M resulting from an increased arterial resistance. At the latter dose, pulmonary capillary pressure increased from 5.8 +/- 0.9 to 9.4 +/- 1.0 mmHg (P < 0.05). When administered in the presence of norepinephrine, 10(-8) and 10(-7) M NPY (n = 6) produced extreme increases in Ppa to 66.1 +/- 20.5 and 114.7 +/- 25.5 mmHg, respectively, that were due primarily to an increased arterial resistance. To determine the significance of circulating NPY as a pulmonary vasoactive agent, we measured plasma NPY-like immunoreactivity in anesthetized rabbits after massively activating the sympathetic nervous system with veratrine. NPY-like immunoreactivity increased from 74 +/- 10 to 111 +/- 10 (SE) pM (P < 0.05). Thus, although NPY is a potent vasoconstrictor in the rabbit lung, it is not likely that plasma NPY concentrations rise sufficiently, even after massive sympathetic nervous system activation, to produce pulmonary vasoconstriction in the intact rabbit.
S A Lang; M B Maron
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  84     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  618-23     Citation Subset:  IM    
Department of Physiology, Northeastern Ohio Universities, College of Medicine, Rootstown 44272, USA.
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MeSH Terms
Cisterna Magna
Hemodynamics / physiology*
Neuropeptide Y / blood,  pharmacology,  physiology*
Norepinephrine / pharmacology
Pulmonary Circulation / drug effects,  physiology*
Sympathetic Nervous System / drug effects,  physiology
Vascular Resistance / drug effects,  physiology
Vasoconstriction / drug effects,  physiology
Vasoconstrictor Agents / pharmacology
Veratrine / administration & dosage,  pharmacology
Grant Support
Reg. No./Substance:
0/Neuropeptide Y; 0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 62-59-9/Veratrine

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