| Effect of neuropeptide Y on hemodynamics of the rabbit lung. | |
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MedLine Citation:
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PMID: 9475874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10(-8) and 10(-7) M NPY increased pulmonary arterial pressure (Ppa) from 11.5 +/- 1.0 (SE) mmHg to, respectively, 16.4 +/- 1.5 and 26.0 +/- 3.8 mmHg (P < 0.05, n = 5 mmHg lungs), with 78 +/- 4% of the increase at 10(-7) M resulting from an increased arterial resistance. At the latter dose, pulmonary capillary pressure increased from 5.8 +/- 0.9 to 9.4 +/- 1.0 mmHg (P < 0.05). When administered in the presence of norepinephrine, 10(-8) and 10(-7) M NPY (n = 6) produced extreme increases in Ppa to 66.1 +/- 20.5 and 114.7 +/- 25.5 mmHg, respectively, that were due primarily to an increased arterial resistance. To determine the significance of circulating NPY as a pulmonary vasoactive agent, we measured plasma NPY-like immunoreactivity in anesthetized rabbits after massively activating the sympathetic nervous system with veratrine. NPY-like immunoreactivity increased from 74 +/- 10 to 111 +/- 10 (SE) pM (P < 0.05). Thus, although NPY is a potent vasoconstrictor in the rabbit lung, it is not likely that plasma NPY concentrations rise sufficiently, even after massive sympathetic nervous system activation, to produce pulmonary vasoconstriction in the intact rabbit. |
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Authors:
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S A Lang; M B Maron |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 84 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-24 Completed Date: 1998-03-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 618-23 Citation Subset: IM |
Affiliation:
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Department of Physiology, Northeastern Ohio Universities, College of Medicine, Rootstown 44272, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cisterna Magna Hemodynamics / physiology* Injections Neuropeptide Y / blood, pharmacology, physiology* Norepinephrine / pharmacology Perfusion Pulmonary Circulation / drug effects, physiology* Rabbits Sympathetic Nervous System / drug effects, physiology Vascular Resistance / drug effects, physiology Vasoconstriction / drug effects, physiology Vasoconstrictor Agents / pharmacology Veratrine / administration & dosage, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-31070/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 62-59-9/Veratrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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