Document Detail

Effect of neu differentiation factor isoforms on neonatal oligodendrocyte function.
MedLine Citation:
PMID:  9418963     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested that neu differentiation factor (NDF), a member of the neuregulin (NRG) family of growth factors, may regulate the development of PNS and CNS glial cells. There is limited information concerning the potential role of NDF on the development of neonatal (immature) oligodendrocytes (OLG) into adult OLG. We now report the effect of the two major isoform families of NDF (NDF alpha and NDF beta) on the development of cultured rat neonatal OLG. Immunocytochemical and western blot analyses of neonatal OLG using anti-erb-B antibodies revealed that these immature OLG express all four members of NRG (erb-B) receptors. Treatment of neonatal OLG with varying concentrations of either NDF alpha or NDF beta did not have a mitogenic effect on cultured neonatal OLG. Pretreatment of immature OLG with either of the NDF isoforms also did not influence the subsequent mitogenicity of other known OLG mitogens. However, treatment of neonatal OLG with either isoform of NDF influenced the survival of these cells by protecting the cells from apoptosis. Additionally, treatment of neonatal OLG with either NDF alpha or NDF beta resulted in more extensive process formation compared to control, non-treated OLG.
T D Raabe; S Suy; A Welcher; G H DeVries
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  50     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-18     Completed Date:  1998-02-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  755-68     Citation Subset:  IM    
Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, Illinois, USA.
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MeSH Terms
Animals, Newborn
Apoptosis / drug effects
Cell Differentiation
Cell Division / drug effects
Cell Survival / drug effects*
Cells, Cultured
Cerebellum / physiology
Cerebral Cortex / cytology,  physiology*
Fibroblast Growth Factor 2 / pharmacology
Glycoproteins / pharmacology*
Nerve Growth Factors / pharmacology
Oligodendroglia / cytology,  drug effects,  physiology*
Rats, Sprague-Dawley
Receptor, erbB-2 / biosynthesis*
Time Factors
Tissue Extracts / pharmacology
Reg. No./Substance:
0/Glycoproteins; 0/Nerve Growth Factors; 0/Neuregulins; 0/Tissue Extracts; 103107-01-3/Fibroblast Growth Factor 2; EC, erbB-2

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