| Effect of neu differentiation factor isoforms on neonatal oligodendrocyte function. | |
| | |
MedLine Citation:
|
PMID: 9418963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous studies have suggested that neu differentiation factor (NDF), a member of the neuregulin (NRG) family of growth factors, may regulate the development of PNS and CNS glial cells. There is limited information concerning the potential role of NDF on the development of neonatal (immature) oligodendrocytes (OLG) into adult OLG. We now report the effect of the two major isoform families of NDF (NDF alpha and NDF beta) on the development of cultured rat neonatal OLG. Immunocytochemical and western blot analyses of neonatal OLG using anti-erb-B antibodies revealed that these immature OLG express all four members of NRG (erb-B) receptors. Treatment of neonatal OLG with varying concentrations of either NDF alpha or NDF beta did not have a mitogenic effect on cultured neonatal OLG. Pretreatment of immature OLG with either of the NDF isoforms also did not influence the subsequent mitogenicity of other known OLG mitogens. However, treatment of neonatal OLG with either isoform of NDF influenced the survival of these cells by protecting the cells from apoptosis. Additionally, treatment of neonatal OLG with either NDF alpha or NDF beta resulted in more extensive process formation compared to control, non-treated OLG. |
| | |
Authors:
|
T D Raabe; S Suy; A Welcher; G H DeVries |
Related Documents
:
|
17962243 - Pain reduction of heel stick in neonates: yakson compared to non-nutritive sucking. 17927303 - Antifungal agents in neonates: issues and recommendations. 10191793 - Perinatal risk and severity of illness in newborns at 6 neonatal intensive care units. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of neuroscience research Volume: 50 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 1997 Dec |
Date Detail:
|
Created Date: 1998-02-18 Completed Date: 1998-02-18 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 755-68 Citation Subset: IM |
Affiliation:
|
Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, Illinois, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn Apoptosis / drug effects Cattle Cell Differentiation Cell Division / drug effects Cell Survival / drug effects* Cells, Cultured Cerebellum / physiology Cerebral Cortex / cytology, physiology* Fibroblast Growth Factor 2 / pharmacology Glycoproteins / pharmacology* Kinetics Nerve Growth Factors / pharmacology Neuregulins Oligodendroglia / cytology, drug effects, physiology* Rats Rats, Sprague-Dawley Receptor, erbB-2 / biosynthesis* Time Factors Tissue Extracts / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Glycoproteins; 0/Nerve Growth Factors; 0/Neuregulins; 0/Tissue Extracts; 103107-01-3/Fibroblast Growth Factor 2; EC 2.7.10.1/Receptor, erbB-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by ...
Next Document: Expression of molecular chaperones and vesicle transport proteins in differentiating oligodendrocyte...