Document Detail

Effect of nepafenac sodium 0.1% on delayed corneal epithelial healing and haze after photorefractive keratectomy: retrospective comparative study.
MedLine Citation:
PMID:  18721717     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess delayed epithelialization and corneal haze related to nepafenac ophthalmic suspension 0.1% (Nevanac) use after photorefractive keratectomy (PRK).
SETTING: Private practice, Beverly Hills, California, USA.
METHODS: This retrospective comparative chart review comprised 69 eyes (44 patients) that were divided into 2 treatment groups that were not statistically significantly different in age or preoperative spherical equivalent. The nepafenac group consisted of 34 eyes (22 patients) that received nepafenac 0.1%, moxifloxacin, and fluorometholone postoperatively. The non-nepafenac group included 35 eyes (22 patients) that received moxifloxacin and fluorometholone only. Patients were seen between 1 day and 5 days postoperatively for evaluation of epithelial healing and haze formation. Delayed epithelialization was defined as healing after day 5. All patients were followed for haze formation for a minimum of 3 months.
RESULTS: Statistical analysis showed no difference between the nepafenac and non-nepafenac groups in delayed epithelialization (P = .61, chi-square test). Neither group had significant corneal haze.
CONCLUSION: Nepafenac did not appear to delay corneal epithelial healing or contribute to haze formation after PRK.
Shahrokh Jalali; Leonard H Yuen; Brian S Boxer Wachler
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  34     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-03     Revised Date:  2013-08-26    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1542-5     Citation Subset:  IM    
Boxer Wachler Vision Institute, 465 North Roxbury Drive, Beverly Hills, CA 90210, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Benzeneacetamides / administration & dosage*
Corneal Opacity / etiology*,  physiopathology
Epithelium, Corneal / drug effects*
Lasers, Excimer
Myopia / surgery
Ophthalmic Solutions / administration & dosage*
Phenylacetates / administration & dosage*
Photorefractive Keratectomy*
Prodrugs / administration & dosage*
Retrospective Studies
Visual Acuity / drug effects
Wound Healing / drug effects*,  physiology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Benzeneacetamides; 0/Ophthalmic Solutions; 0/Phenylacetates; 0/Prodrugs; 0J9L7J6V8C/nepafenac

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