| Effect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period. | |
| | |
MedLine Citation:
|
PMID: 8640469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Our objective was to evaluate the effect on the neonatal thyroid function of povidone-iodine (PVP-I) used on mothers during the perinatal period. METHODS: Eight consecutive-term pregnant women were randomly separated into 4 groups. Either PVP-1 or benzethonium chloride (BC) was used to disinfect both maternal skin during labor and vaginal lacerations after delivery in Group I and IV; and PVP-1 or BC was supplied to either skin or lacerations in Groups II and III. On day 5, we measured the iodide concentration in breast milk and random urine of neonates, and the levels of neonatal thyroid-stimulating hormone (TSH) and free thyroxine. RESULTS: The TSH levels in Group I and the breast-milk iodide concentrations in Groups I and II were significantly higher than those in Group IV (p < 0.05). Dietary iodide intake from breast milk correlated significantly with urinary iodide concentrations (r = 0.52, p < 0.001). In our clinic, the recall rate at the time of screening for congenital hypothyroidism was significantly decreased by discontinuing the use of PVP-I (4.47% vs 0.74%, p < 0.001). CONCLUSIONS: These findings suggest that the use of PVP-I on mothers is associated with transient neonatal hyperthyrotropinemia, in which breast milk might play an important role. Therefore, we recommend that the use of PVP-I be avoided during labor. |
| | |
Authors:
|
Y Koga; H Sano; Y Kikukawa; T Ishigouoka; M Kawamura |
Related Documents
:
|
2380819 - Longitudinal assessment of l-thyroxine therapy for congenital hypothyroidism. 9917489 - Congenital hypothyroidism and nonimmune hydrops fetalis: associated? 12012289 - Transient hypothyroxinemia of prematurity is associated with abnormal cranial ultrasoun... 18556969 - Geographical epidemiology of neonatal transitory hypothyroidism. trend evidence in cent... 15506679 - A high prevalence of consanguineous and severe congenital hypothyroidism in an iranian ... 9063429 - Pseudotumor cerebri in an infant after l-thyroxine therapy for transient neonatal hypot... 15467539 - Neonatal morbidity in second twin according to gestational age at birth and mode of del... 5347179 - Massive subaponeurotic haemorrhage in infants born by vacuum extraction. 10380089 - Effects of inhaled beclomethasone compared to systemic dexamethasone on lung inflammati... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of obstetrics and gynaecology (Tokyo, Japan) Volume: 21 ISSN: 1340-9654 ISO Abbreviation: J Obstet Gynaecol (Tokyo 1995) Publication Date: 1995 Dec |
Date Detail:
|
Created Date: 1996-07-16 Completed Date: 1996-07-16 Revised Date: 2009-07-30 |
Medline Journal Info:
|
Nlm Unique ID: 9515066 Medline TA: J Obstet Gynaecol (Tokyo 1995) Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 581-5 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Nikko Memorial Hospital, Muroran, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Infective Agents, Local
/
administration & dosage,
pharmacokinetics* Delivery, Obstetric* Female Humans Infant, Newborn / blood* Iodides / analysis, urine Milk, Human / chemistry Povidone-Iodine / administration & dosage, pharmacokinetics* Pregnancy Thyroid Gland / drug effects*, physiology Thyrotropin / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Infective Agents, Local; 0/Iodides; 25655-41-8/Povidone-Iodine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anaphylactic reaction to cefazolin in pregnancy.
Next Document: A randomized study comparing suture with non-suture cold-knife conization.