Document Detail


Effect of nebulized furosemide in terminally ill cancer patients with dyspnea.
MedLine Citation:
PMID:  14575057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the effect of ultrasonically nebulized furosemide (20 mg) on dyspnea uncontrollable by standard therapy in patients with terminal cancer. Dyspnea was evaluated using the Cancer Dyspnea Scale (CDS) before and 60 min after inhalation. Changes in arterial blood gases, hemoglobin oxygen saturation (SpO2), heart rate (HR), and respiratory rate (RR) also were evaluated. In 12 of 15 patients (80%), total dyspnea scores by CDS improved significantly after inhalation of furosemide (P = 0.007), especially concerning a reduced sense of effort (P = 0.013) and reduced anxiety (P = 0.04). No significant changes were observed in the partial pressure of oxygen in arterial blood (PaO2), the partial pressure of carbon dioxide in arterial blood (PaCO2), SpO2, HR, or RR. Inhalation of nebulized furosemide appears to be effective against dyspnea in terminally ill cancer patients.
Authors:
Hiroyuki Kohara; Hiroshi Ueoka; Keisuke Aoe; Tadashi Maeda; Hiroyasu Takeyama; Ryusei Saito; Yasuo Shima; Yosuke Uchitomi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pain and symptom management     Volume:  26     ISSN:  0885-3924     ISO Abbreviation:  J Pain Symptom Manage     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-23     Completed Date:  2003-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605836     Medline TA:  J Pain Symptom Manage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  962-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, National Sanyo Hospital, Yamaguchi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Chloride Channels / antagonists & inhibitors
Critical Illness / therapy*
Dyspnea / drug therapy*,  etiology*
Furosemide / administration & dosage*
Humans
Nebulizers and Vaporizers
Neoplasms / complications*
Ultrasonics
Chemical
Reg. No./Substance:
0/Chloride Channels; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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