Document Detail

Effect of nebulised lignocaine on the quality of induction of anaesthesia in cigarette smokers.
MedLine Citation:
PMID:  9349064     Owner:  NLM     Status:  MEDLINE    
We have assessed the effect of nebulised lignocaine, given pre-operatively, upon the quality of induction of anaesthesia in cigarette smokers. Seventy-five patients were studied in a double-blind randomised fashion, receiving a nebuliser of either 4 ml 0.9% NaCl or 4 ml 4% lignocaine. All patients received a standardised anaesthetic consisting of thiopentone followed by progressive increments of enflurane. Thirty-three out of 38 patients (87%) who received nebulised lignocaine had induction without adverse events, compared with 25 out of 37 patients (68%) in the nebulised saline group (Chi-squared test p < 0.05). We conclude that the use of nebulised lignocaine, administered pre-operatively, improves the quality of induction of anaesthesia in cigarette smokers.
R Caranza; J H Raphael; N Nandwani; J A Langton
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  52     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-13     Completed Date:  1997-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  849-52     Citation Subset:  AIM; IM    
University Department of Anaesthesia, Leicester Royal Infirmary, UK.
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MeSH Terms
Administration, Inhalation
Anesthesia, General*
Anesthetics, Local / pharmacology*
Double-Blind Method
Lidocaine / pharmacology*
Middle Aged
Oxygen / blood
Preanesthetic Medication
Respiration Disorders / etiology,  prevention & control*
Smoking / adverse effects*
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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