Document Detail


Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines.
MedLine Citation:
PMID:  11913557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of two natural retinoids and synthetic retinoids with or without retinoid synergists on the proliferation and differentiation of 3 melanoma cell lines were investigated in vitro. No retinoids showed significant growth inhibitory effect on these cell lines when used alone, however, cell differentiation and significant growth inhibition were observed when treated with a combination of retinoids and a retinoid synergist. This study may suggest that, though the cells showed low susceptibilities when retinoids were treated alone, the combination of retinoids and a retinoid synergist may be effective to control the growth of canine melanoma cell lines.
Authors:
Emi Ohashi; Kaori Inoue; Hiroyuki Kagechika; Sung-Hyeok Hong; NakagawaTakayuki; Tomoko Takahashi; Manabu Mochizuki; Ryouhei Nishimura; Nobuo Sasaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  64     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-11-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Benzazepines / pharmacology
Benzoic Acids / pharmacology
Cell Division / drug effects
Cell Line
Cell Transformation, Neoplastic / drug effects*
Dogs
Drug Synergism
In Situ Nick-End Labeling
Melanoma / pathology*
Retinoids / chemical synthesis,  pharmacology*
Structure-Activity Relationship
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Benzazepines; 0/Benzoic Acids; 0/HX 630; 0/Retinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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