Document Detail

Effect of natural and synthetic retinoids on the proliferation and differentiation of three canine melanoma cell lines.
MedLine Citation:
PMID:  11913557     Owner:  NLM     Status:  MEDLINE    
The effect of two natural retinoids and synthetic retinoids with or without retinoid synergists on the proliferation and differentiation of 3 melanoma cell lines were investigated in vitro. No retinoids showed significant growth inhibitory effect on these cell lines when used alone, however, cell differentiation and significant growth inhibition were observed when treated with a combination of retinoids and a retinoid synergist. This study may suggest that, though the cells showed low susceptibilities when retinoids were treated alone, the combination of retinoids and a retinoid synergist may be effective to control the growth of canine melanoma cell lines.
Emi Ohashi; Kaori Inoue; Hiroyuki Kagechika; Sung-Hyeok Hong; NakagawaTakayuki; Tomoko Takahashi; Manabu Mochizuki; Ryouhei Nishimura; Nobuo Sasaki
Related Documents :
20587137 - Cardiac cell generation from encapsulated embryonic stem cells in static and scalable c...
6943147 - Mechanisms controlling the kinetics in proliferation and differentiation of populations...
21367277 - 296 production of hemizygous and homozygous embryonic stem cell-derived neural progenit...
12517427 - Synthesis and evaluation of new 5-fluorouracil antitumor cell differentiating derivatives.
23108867 - Comparison of cellular responses across multiple passage numbers in ba/f3-bcr-abl cells...
9322247 - Dna degradation in mural granulosa cells of non- and slightly atretic follicles of fres...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  64     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-11-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apoptosis / drug effects
Benzazepines / pharmacology
Benzoic Acids / pharmacology
Cell Division / drug effects
Cell Line
Cell Transformation, Neoplastic / drug effects*
Drug Synergism
In Situ Nick-End Labeling
Melanoma / pathology*
Retinoids / chemical synthesis,  pharmacology*
Structure-Activity Relationship
Tumor Cells, Cultured
Reg. No./Substance:
0/Benzazepines; 0/Benzoic Acids; 0/HX 630; 0/Retinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Identification of genotypes of Cryptosporidium parvum isolates from a patient and a dog in Japan.
Next Document:  Hyaluronidase is not essential for the lethality of Erysipelothrix rhusiopathiae infection in mice.