Document Detail

Effect of natural peptide YY on blood flow and exocrine secretion of pancreas in dogs.
MedLine Citation:
PMID:  3378477     Owner:  NLM     Status:  MEDLINE    
Little is known regarding the mechanism by which peptide YY exerts an inhibitory effect on exocrine pancreatic secretion. The purpose of this study is to determine if peptide YY affects pancreatic blood flow with simultaneous measurement of exocrine pancreatic secretion in dogs. Pancreatic blood flow was measured by a laser Doppler flowmeter which allows continuous measurement of tissue blood flow. Natural peptide YY (0.1, 0.5, 1 microgram/kg) was infused intravenously as a bolus under background infusion of secretin (1 unit/kg/hr) in combination with cholecystokinin-octapeptide (0.1 microgram/kg/hr). Peptide YY caused a reduction of pancreatic blood flow in a dose-dependent manner as well as inhibition of pancreatic protein output, attaining the maximal reduction (28 +/- 4%) and inhibition (45 +/- 9%) at a dose of 1 microgram/kg, respectively. Simultaneous and continuous observation on tissue blood flow and exocrine secretion of the pancreas revealed that there was a highly significant correlation between the percent reduction of pancreatic blood flow and that of volume of pancreatic juice in response to peptide YY (r = 0.849, P less than 0.001). This study provides evidence that the mechanism of peptide YY-induced inhibition of exocrine pancreatic secretion is mediated, at least partly, through the decreased pancreatic blood flow.
K Inoue; R Hosotani; K Tatemoto; H Yajima; T Tobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  33     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-07-28     Completed Date:  1988-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  828-32     Citation Subset:  AIM; IM    
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Gastrointestinal Hormones / pharmacology*
Pancreas / blood supply,  drug effects*,  secretion
Pancreatic Juice / secretion*
Peptide YY
Peptides / pharmacology*
Regional Blood Flow
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Peptides; 106388-42-5/Peptide YY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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