| Effect of narrow-band UVB therapy on inflammatory markers and body fat composition in moderate to severe psoriasis. | |
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MedLine Citation:
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PMID: 22309899 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Previous studies have shown increased prevalence of metabolic syndrome in psoriasis patients. Objectives: To characterise the anthropometric and metabolic profile of Spanish patients with moderate to severe psoriasis compared to controls without psoriasis matched for gender, age and body mass index, and evaluate the impact of narrow-band ultraviolet B (NBUVB) therapy on patient profiles. Methods: Baseline waist circumference, body fat composition, lipid and carbohydrate and calcium metabolism profile, inflammation markers, homocysteine and vitamins D, B6, B12 and folic acid of 50 psoriasis patients and 50 matched controls were recorded then evaluated after NBUVB in psoriatic patients and correlated with clinical outcome. Results: Despite very similar body mass indexes, 52% of patients met International Diabetes Foundation (IDF) criteria for metabolic syndrome compared to 42% of controls (p=0,01); body fat was 29.86% in patients and 27.96% in controls (p=0,037), correlating with waist circumference; whilst patient atherogenic profiles were less favourable, with higher apolipoprotein B (Apo-B) and LDL cholesterol than controls, and both patients and controls showed insufficient vitamin D serum levels (<20 ng/ml). Mean improvement of Psoriasis Area and Severity Index (PASI) after NBUVB was 78.21%. Ferritin, B12 and C-reactive protein (CRP) decreased significantly after NBUVB therapy. Vitamin D levels reached adequate levels after phototherapy; however, no relationship with PASI improvement was observed. Conclusions: We characterised inflammatory and atherogenic profiles of Spanish psoriasis patients compared to matched controls. After NBUVB therapy we demonstrated improvement in psoriasis and some systemic inflammation markers, which were not mediated by enhancement of vitamin D synthesis. |
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Authors:
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J Romaní; A Caixas; J M Carrascosa; M Ribera; M Rigla; J Luelmo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 British Association of Dermatologists. |
Affiliation:
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Department of Dermatology, Corporació Sanitària Universitària Parc Taulí, Institut Universitary Parc Taulí, Autonomous University of Barcelona, Spain. Department of Diabetes, Endocrinology and Nutrition. Corporació Sanitària Universitària Parc Taulí, Institut Universitary Parc Taulí, Autonomous University of Barcelona, Spain Department of Dermatology, Hospital Universitari Germans Trias i Pujol,. Autonomous University of Barcelona, Badalona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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