Document Detail


Effect of narrowband ultraviolet B therapy on inflammatory markers and body fat composition in moderate to severe psoriasis.
MedLine Citation:
PMID:  22309899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies have shown increased prevalence of metabolic syndrome in patients with psoriasis.
OBJECTIVES: To characterize the anthropometric and metabolic profile of Spanish patients with moderate to severe psoriasis compared with controls without psoriasis matched for gender, age and body mass index (BMI), and to evaluate the impact of narrowband ultraviolet B (NB-UVB) therapy on patient profiles.
METHODS: Baseline waist circumference, body fat composition, lipid, carbohydrate and calcium metabolism profile, inflammation markers, homocysteine, vitamins D, B(6) and B(12) and folic acid of 50 patients with psoriasis and 50 matched controls were recorded then evaluated after NB-UVB in patients with psoriasis and correlated with clinical outcome.
RESULTS: Despite very similar BMIs, 54% of patients met International Diabetes Foundation criteria for metabolic syndrome compared with 42% of controls (P = 0·01); body fat was 29·9% in patients and 28·0% in controls (P = 0·037), correlating with waist circumference; while patient atherogenic profiles were less favourable, with higher apolipoprotein B and low density lipoprotein cholesterol than controls, and both patients and controls showed insufficient vitamin D serum levels (< 20 ng mL(-1)). Mean improvement of Psoriasis Area and Severity Index (PASI) after NB-UVB was 78·2%. Ferritin, B(12) and C-reactive protein decreased significantly after NB-UVB therapy. Vitamin D levels reached adequate levels after phototherapy; however, no relationship with PASI improvement was observed.
CONCLUSIONS: We characterized inflammatory and atherogenic profiles of Spanish patients with psoriasis compared with matched controls. After NB-UVB therapy we demonstrated improvement in psoriasis and some systemic inflammation markers, which were not mediated by enhancement of vitamin D synthesis.
Authors:
J Romaní; A Caixàs; J M Carrascosa; M Ribera; M Rigla; J Luelmo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  166     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-25     Completed Date:  2012-08-30     Revised Date:  2012-09-25    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1237-44     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.
Affiliation:
Department of Dermatology, Corporació Sanitària Universitària Parc Taulí, Institut Universitari Parc Taulí, Autonomous University of Barcelona, 08208 Sabadell, Barcelona, Spain. jromani@tauli.cat
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / metabolism
Body Fat Distribution
Body Mass Index
Calcifediol / metabolism
Carbohydrate Metabolism
Case-Control Studies
Cholesterol, HDL / metabolism
Cholesterol, LDL / metabolism
Female
Humans
Male
Metabolic Syndrome X / complications,  pathology
Middle Aged
Psoriasis / complications,  pathology,  radiotherapy*
Spain
Treatment Outcome
Ultraviolet Therapy / methods*
Waist Circumference
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 19356-17-3/Calcifediol
Comments/Corrections
Comment In:
Br J Dermatol. 2012 Aug;167(2):457-8; author reply 458   [PMID:  22835025 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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