Document Detail


Effect of naloxone on the pulmonary vascular responses to graded levels of intracranial hypertension in anesthetized sheep.
MedLine Citation:
PMID:  6650974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTROL: 16 +/- 3 cmH2O; ICP: 60 mmHg = 16 +/- 2 cmH2O; ICP: 100 mmHg = 23 +/- 2 cmH2O), cardiac output (
CONTROL: 2.7 +/- 0.1 L/min; ICP: 60 mmHg = 3.3 +/- 0.05, p less than 0.05; ICP: 100 mmHg = 5.3 +/- 1.0, p less than 0.05), lung lymph flow (
CONTROL: 94 +/- 8% baseline; ICP: 60 mmHg = 193 +/- 25% baseline, p less than 0.05; ICP: 100 mmHg = 285 +/- 38% baseline, p less than 0.05), PS urea (
CONTROL: 7.0 +/- 0.5 ml/s; ICP: 60 mmHg = 11.0 +/- 3.7 ml/s; ICP: 100 mmHg = 12.4 +/- 1.3 ml/s, p less than 0.05), and VH2O (CONTROL: 93 +/- 8% baseline; ICP: 60 mmHg = 112 +/- 6% of baseline; ICP: 100 mmHg = 129 +/- 13% of baseline, p less than 0.05) proportional to the level of ICP. Sheep with ICP raised to 100 mmHg had modestly increased lung water (pulmonary edema).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
B T Peterson; J C Ross; K L Brigham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  128     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2014-07-25    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1024-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Blood Pressure / drug effects
Body Water / analysis
Capillary Permeability / drug effects
Cardiac Output / drug effects
Intracranial Pressure*
Lung / analysis,  physiology
Lymph / physiology
Naloxone / pharmacology*
Pulmonary Circulation / drug effects*
Pulmonary Edema / physiopathology*
Sheep
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
HL-19153/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
36B82AMQ7N/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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