Document Detail

Effect of nalidixic acid on DNA replication by toluene-treated Escherichia coli.
MedLine Citation:
PMID:  4579007     Owner:  NLM     Status:  MEDLINE    
Nalidixic acid inhibits DNA synthesis in toluene-treated E. coli, strain B/r, as it is well known to do in vivo. Both semiconservative and repair syntheses are affected, though to different degrees. Density-transfer experiments indicate that chromosomal replication is reinitiated when nalidixic acid is removed from toluene-treated cells after exposure to the acid for one generation in vivo. For cells in vivo or after toluene-treatment, reinitiation is not seen in asynchronous cultures exposed briefly to nalidixic acid or in cells prevented from synthesizing proteins during their exposure to the acid. Reinitiation occurs at the chromosomal origin but, unlike the effect seen in vivo, replication at the old site persists.
R M Burger; D A Glaser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  70     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1973 Jul 
Date Detail:
Created Date:  1973-10-09     Completed Date:  1973-10-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1955-8     Citation Subset:  IM    
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MeSH Terms
Carbon Isotopes
Cytosine Nucleotides / metabolism
DNA Replication / drug effects*
Depression, Chemical
Escherichia coli / drug effects,  metabolism*
Nalidixic Acid / pharmacology*
Nucleotides / metabolism
Thymine / metabolism
Toluene / pharmacology
Reg. No./Substance:
0/Carbon Isotopes; 0/Cytosine Nucleotides; 0/Nucleotides; 10028-17-8/Tritium; 108-88-3/Toluene; 389-08-2/Nalidixic Acid; 65-71-4/Thymine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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