Document Detail


Effect of naftidrofuryl on high energy phosphates, glycogen, lactate and pyruvate in mouse hearts during asphyxia and post-asphyctic recovery.
MedLine Citation:
PMID:  7447560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of naftidrofuryl (40 micrograms/g i.p.) on the ATP, phosphocreatine (PC), glycogen, lactate and pyruvate contents of the heart during respiratory arrest and postanoxic recovery was studied in mice. Naftidrofuryl increased he PC-content of the heart of normal mice. It did not prevent the metabolic changes brought about by 1 min anoxia but accelerated the post anoxic recovery of the depleted PC-content on account of delayed replenishment of the reduced glycogen stores. The changes in the ATP, lactate and pyruvate contents were not affected.
Authors:
C J Estler; R Böcker; W Schinzel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  247     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-02-24     Completed Date:  1981-02-24     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  39-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Animals
Asphyxia / metabolism*
Energy Metabolism / drug effects*
Furans / pharmacology*
Glycogen / metabolism
Heart / drug effects
Lactates / metabolism
Male
Mice
Myocardium / metabolism*
Nafronyl / pharmacology*
Phosphates / metabolism
Phosphocreatine / metabolism
Pyruvates / metabolism
Chemical
Reg. No./Substance:
0/Furans; 0/Lactates; 0/Phosphates; 0/Pyruvates; 31329-57-4/Nafronyl; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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