| Effect of n-3 fatty acids on the key enzymes involved in cholesterol and triglyceride turnover in rat liver. | |
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MedLine Citation:
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PMID: 1895886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of long-chain n-3 fatty acids on hepatic key enzymes of cholesterol metabolism and triglyceride biosynthesis was investigated in two rat models. In the first model, rats were intravenously infused for two weeks with a fat emulsion containing 20% of triglycerides in which either n-6 or n-3 fatty acids predominated. The treatment with n-3 fatty acids led to a reduction primarily of serum cholesterol (45%), but also of serum triglycerides (18%). HMG-CoA reductase activity and cholesterol 7 alpha-hydroxylase activity were reduced by 45% and 36%, respectively. There were no significant effects on diacylglycerol acyltransferase (DGAT) or phosphatidate phosphohydrolase (PAP) activities. In the second model, rats were fed a diet enriched with sucrose, coconut oil and either sunflower oil (n-6 fatty acids) or fish oil (long-chain n-3 fatty acid ethyl esters). The treatment with n-3 fatty acids decreased serum triglycerides (41%) and, to a lesser extent, serum cholesterol (17%). Neither glycerol 3-phosphate acyltransferase (GPAT) or DGAT were affected by n-3 fatty acids. In contrast, PAP activity was reduced by 26%. HMG-CoA reductase was not significantly affected, whereas cholesterol 7 alpha-hydroxylase activity was reduced by 36%. The results indicate that part of the TG-lowering effect of long-chain n-3 fatty acids may be mediated by inhibition of the soluble phosphatidate phosphohydrolase. The effect on serum cholesterol may be partly due to inhibition of HMG-CoA reductase. |
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Authors:
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A al-Shurbaji; C Larsson-Backström; L Berglund; G Eggertsen; I Björkhem |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lipids Volume: 26 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-10-21 Completed Date: 1991-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 385-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, Karolinska Institute Huddinge University Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyltransferases
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metabolism Animals Cholesterol / blood, metabolism* Cholesterol 7-alpha-Hydroxylase / metabolism* Diacylglycerol O-Acyltransferase Dietary Fats / pharmacology* Fatty Acids, Omega-3 / pharmacology* Fish Oils / pharmacology* Hydroxymethylglutaryl CoA Reductases / metabolism* Liver / drug effects, enzymology* Male Phosphatidate Phosphatase / metabolism Plant Oils / pharmacology* Rats Rats, Inbred Strains Soybean Oil / pharmacology* Triglycerides / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Plant Oils; 0/Triglycerides; 57-88-5/Cholesterol; 8001-21-6/sunflower seed oil; 8001-22-7/Soybean Oil; 8001-31-8/coconut oil; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase; EC 2.3.-/Acyltransferases; EC 2.3.1.20/Diacylglycerol O-Acyltransferase; EC 3.1.3.4/Phosphatidate Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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