| Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. | |
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MedLine Citation:
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PMID: 16650969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary lipid manipulation may affect a great number of immune parameters, such as lymphocyte proliferation, cytokine synthesis. In this study, lymphocytes of diabetic type 2 were incubated with different polyunsaturated fatty acid (docosahexaenoic, eicosapentaenoic, arachidonic acid) for investigated their effect on lymphoproliferation response, the concentration of interleukin 2 produced in each essay and phospholipid fatty acid composition of lymphocyte membrane. Our results found that the concanavalin A and insulin increase significantly the proliferative response while eicosapentaenoic, arachidonic and docosahexaenoic acid inhibited that by different degrees: 47%, 37% and 19%, respectively, for healthy subjects and 39%, 29% and 13% for diabetes. However, the concentration of IL-2 produced in presence of either docosahexaenoic, eicosapentaenoic or arachidonic acid was significantly reduced by 36%, 32% and 39%, respectively, in controls while 16%, 15% and 23%, respectively, in diabetics. On the other hand, the tested fatty acids demonstrated a major impact on the fatty acid composition of different phospholipid fractions of lymphocyte membrane but these fractions were different in their response to each fatty acid examined. For instance, the addition of docosahexaenoic acid to culture media was accompanied with a predominant composition of docosahexaenoic acid in phospholipid fractions. Also, our results showed a notable increased proportion of arachidonic, eicosapentaenoic and docosahexaenoic acids in control phospholipid fractions than those of diabetic. |
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Authors:
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A Alnajjar; D Chabane Sari; N Abuharfeil; M Hudaib; T Aburjai |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article Date: 2006-05-02 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 74 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-08 Completed Date: 2006-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 347-56 Citation Subset: IM |
Affiliation:
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Laboratory of Cellular Biology, Department of Biology, University of Tlemcen, P.O. Box 119, Tlemcen 13000, Algeria. alnajjar_as@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arachidonic Acid
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pharmacology Cell Proliferation / drug effects Diabetes Mellitus, Type 2 / blood* Docosahexaenoic Acids / pharmacology Eicosapentaenoic Acid / pharmacology Fatty Acids, Omega-3 / pharmacology* Fatty Acids, Omega-6 / pharmacology* Female Humans Insulin / pharmacology Interleukins / biosynthesis*, metabolism Jordan Male Membrane Lipids / chemistry Phospholipids / chemistry* Subcellular Fractions T-Lymphocytes / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Interleukins; 0/Membrane Lipids; 0/Phospholipids; 11061-68-0/Insulin; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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