Document Detail


Effect of myricetin on blood pressure and metabolic alterations in fructose hypertensive rats.
MedLine Citation:
PMID:  20645789     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Fructose feeding induces a rise in blood pressure in normal rats and is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. We have examined the effect of myricetin (100 and 300 mg/kg, p.o. for 6 weeks) isolated from Vitis vinifera Linn. (Vitaceae) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, and insulin in fructose-induced hypertension. Myricetin reduced systolic blood pressure and vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose. The cumulative concentration-response curve (CCRC) of Ang II was shifted toward the right in rats treated with myricetin, using isolated strips of ascending colon. The results suggest that myricetin could prevent the development of high blood pressure induced by a diet rich in fructose, probably by reversing the metabolic alterations induced by fructose. In conclusion, myricetin has antihypertensive action in the fructose model.
Authors:
Sandip Godse; Mahalaxmi Mohan; Veena Kasture; Sanjay Kasture
Related Documents :
25427289 - The influence of positive end-expiratory pressure on surgical field conditions during f...
7385009 - The treatment of hypotension due to acute experimental spinal cord compression injury.
540439 - Modulation of sympathetic vascular tone by prostaglandins in corticosterone-induced hyp...
15464289 - Spaceflight alters the fiber composition of the aortic nerve in the developing rat.
7613529 - Effects of glycyrrhizic acid on right atrial pressure and pulmonary vasculature in rats.
4052729 - Comparison of the cardiovascular effects of meptazinol and naloxone following haemorrha...
7154009 - 4-aroyl-1,3-dihydro-2h-imidazol-2-ones, a new class of cardiotonic agents.
12470399 - Increase of intracranial pressure after hypothermic circulatory arrest in a chronic por...
11940919 - Ect for post-stroke depression: beta blockade to modify rise in blood pressure.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmaceutical biology     Volume:  48     ISSN:  1744-5116     ISO Abbreviation:  Pharm Biol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812552     Medline TA:  Pharm Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  494-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, M.G.V.'s Pharmacy College, Panchavati, Nasik, Maharashtra, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hippophae rhamnoides attenuates nicotine-induced oxidative stress in rat liver.
Next Document:  Restoration of acetylcholinesterase activity by Euphorbia hirta in discrete brain regions of chronic...