Document Detail

Effect of myricetin on blood pressure and metabolic alterations in fructose hypertensive rats.
MedLine Citation:
PMID:  20645789     Owner:  NLM     Status:  In-Process    
Fructose feeding induces a rise in blood pressure in normal rats and is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. We have examined the effect of myricetin (100 and 300 mg/kg, p.o. for 6 weeks) isolated from Vitis vinifera Linn. (Vitaceae) on systolic blood pressure (SBP), vascular reactivity, serum glucose, triglycerides, cholesterol, and insulin in fructose-induced hypertension. Myricetin reduced systolic blood pressure and vascular reactivity changes to catecholamines and reversed the metabolic alterations induced by fructose. The cumulative concentration-response curve (CCRC) of Ang II was shifted toward the right in rats treated with myricetin, using isolated strips of ascending colon. The results suggest that myricetin could prevent the development of high blood pressure induced by a diet rich in fructose, probably by reversing the metabolic alterations induced by fructose. In conclusion, myricetin has antihypertensive action in the fructose model.
Sandip Godse; Mahalaxmi Mohan; Veena Kasture; Sanjay Kasture
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmaceutical biology     Volume:  48     ISSN:  1744-5116     ISO Abbreviation:  Pharm Biol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812552     Medline TA:  Pharm Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  494-8     Citation Subset:  IM    
Department of Pharmacology, M.G.V.'s Pharmacy College, Panchavati, Nasik, Maharashtra, India.
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