Document Detail

Effect of myocardial infarction and ischemia on induction of cardiac reentries and ventricular fibrillation.
MedLine Citation:
PMID:  8919348     Owner:  NLM     Status:  MEDLINE    
The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated is then simulated. This is made using a Gaussian distribution characterized by its mean and standard deviation. These simulations show that ischemia is capable of initiating reentry phenomena which propagate through the whole ventricle; they are responsible for ventricular fibrillation which causes sudden cardiac death, even when ischemia only involves limited parts of the myocardium. Statistical study of the probability of reentries as a function of both of the size of ischemic zones and the rate of dispersion of refractory periods shows that the latter parameter is of primary importance in triggering cardiac reentries.
A L Bardou; P M Auger; S Achour; P Dumee; P J Birkui; M C Govaere
Related Documents :
22050028 - Anatomic assessment of variations in myocardial approaches to the atrioventricular node.
19395548 - Reductions in mitochondrial o(2) consumption and preservation of high-energy phosphate ...
12724648 - Temporal changes and histologic relation of postsystolic thickening in an animal model ...
2621768 - Prevalence and clinical significance of silent myocardial ischemia in exercise test.
138218 - Relative role of factors associated with cerebral infarction and cerebral hemorrhage. a...
11696828 - Combined dipyridamole and dobutamine echocardiography in myocardial hibernation: compar...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biotheoretica     Volume:  43     ISSN:  0001-5342     ISO Abbreviation:  Acta Biotheor.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0421520     Medline TA:  Acta Biotheor     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  363-72     Citation Subset:  IM    
Hopital Broussais, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Hypoxia / physiology
Computer Simulation
Death, Sudden, Cardiac / etiology
Models, Cardiovascular
Myocardial Infarction / physiopathology*
Myocardial Ischemia / physiopathology*
Nonlinear Dynamics
Normal Distribution
Tachycardia, Atrioventricular Nodal Reentry / physiopathology*
Ventricular Fibrillation / physiopathology*
Ventricular Function

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modelling nonlinear integration of synaptic signals by neurones.
Next Document:  Spatio-temporal self-organization of bone mineral metabolism and trabecular structure of primary bon...