| Effect of muscular exercise by bicycle ergometer on erythrocyte purine nucleotides. | |
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MedLine Citation:
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PMID: 7875643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of muscular exercise by bicycle ergometer on erythrocyte purine nucleotides was investigated in 6 athletes. Muscular exercise increased the concentration of inosine monophosphate from 5.9 +/- 1.1 to 7.3 +/- 1.3 nmol/ml in venous erythrocytes and from 5.7 +/- 1.0 to 6.8 +/- 1.4 nmol/ml in arterial erythrocytes, respectively, while it decreased the concentrations of adenosine diphosphate and adenosine monophosphate from 189.3 +/- 42.7 to 141.2 +/- 26.9 and from 26.0 +/- 7.8 to 15.7 +/- 4.3 nmol/ml in venous erythrocytes and also decreased their concentrations from 195.1 +/- 51.0 to 141 +/- 29.2 and from 26.5 +/- 9.6 to 14.8 +/- 3.0 nmol/ml in arterial erythrocytes, respectively. The muscular exercise also increased the concentration of inorganic phosphate in venous plasma from 1.12 +/- 0.12 to 1.46 +/- 0.22 mmol/l, that of NH3 in blood from 41.90 +/- 6.91 to 150.22 +/- 50.80 mumol/l, that of lactic acid in blood from 7.90 +/- 1.71 to 61.03 +/- 18.43 mg/dl and that of hypoxanthine in venous plasma from 1.32 +/- 0.36 to 18.14 +/- 4.87 mumol/l, respectively. Therefore, in vitro study was performed to investigate whether inorganic phosphate, NH4Cl, lactic acid or hypoxanthine affects nucleotides in erythrocytes. After 2 hour-incubation, 2 mM inorganic phosphate increased the erythrocyte concentration of inosine monophosphate 1.6 fold but decreased the erythrocyte concentrations of adenosine monophosphate and adenosine diphosphate 0.72 and 0.89 fold, respectively, in the suspension (pH 7.35), as compared with 1 mM inorganic phosphate. However NH4Cl, lactic acid or hypoxanthine did not affect erythrocyte purine nucleotides.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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T Yamamoto; Y Moriwaki; S Takahashi; H Ishizashi; K Higashino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 26 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1995-04-06 Completed Date: 1995-04-06 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 504-8 Citation Subset: IM; S |
Affiliation:
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Third Department of Internal Medicine, Hyogo College of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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blood Adenosine Monophosphate / blood Adult Ammonium Chloride / blood, pharmacology Erythrocytes / metabolism* Exercise / physiology* Guanosine Diphosphate / blood Guanosine Triphosphate / blood Humans Hypoxanthine Hypoxanthines / blood, pharmacology Inosine Monophosphate / blood Lactates / blood, pharmacology Lactic Acid Male Muscles / physiology* Phosphates / blood, pharmacology Purine Nucleotides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Hypoxanthines; 0/Lactates; 0/Phosphates; 0/Purine Nucleotides; 12125-02-9/Ammonium Chloride; 131-99-7/Inosine Monophosphate; 146-91-8/Guanosine Diphosphate; 50-21-5/Lactic Acid; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 68-94-0/Hypoxanthine; 86-01-1/Guanosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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