Document Detail

Effect of muscular exercise by bicycle ergometer on erythrocyte purine nucleotides.
MedLine Citation:
PMID:  7875643     Owner:  NLM     Status:  MEDLINE    
The effect of muscular exercise by bicycle ergometer on erythrocyte purine nucleotides was investigated in 6 athletes. Muscular exercise increased the concentration of inosine monophosphate from 5.9 +/- 1.1 to 7.3 +/- 1.3 nmol/ml in venous erythrocytes and from 5.7 +/- 1.0 to 6.8 +/- 1.4 nmol/ml in arterial erythrocytes, respectively, while it decreased the concentrations of adenosine diphosphate and adenosine monophosphate from 189.3 +/- 42.7 to 141.2 +/- 26.9 and from 26.0 +/- 7.8 to 15.7 +/- 4.3 nmol/ml in venous erythrocytes and also decreased their concentrations from 195.1 +/- 51.0 to 141 +/- 29.2 and from 26.5 +/- 9.6 to 14.8 +/- 3.0 nmol/ml in arterial erythrocytes, respectively. The muscular exercise also increased the concentration of inorganic phosphate in venous plasma from 1.12 +/- 0.12 to 1.46 +/- 0.22 mmol/l, that of NH3 in blood from 41.90 +/- 6.91 to 150.22 +/- 50.80 mumol/l, that of lactic acid in blood from 7.90 +/- 1.71 to 61.03 +/- 18.43 mg/dl and that of hypoxanthine in venous plasma from 1.32 +/- 0.36 to 18.14 +/- 4.87 mumol/l, respectively. Therefore, in vitro study was performed to investigate whether inorganic phosphate, NH4Cl, lactic acid or hypoxanthine affects nucleotides in erythrocytes. After 2 hour-incubation, 2 mM inorganic phosphate increased the erythrocyte concentration of inosine monophosphate 1.6 fold but decreased the erythrocyte concentrations of adenosine monophosphate and adenosine diphosphate 0.72 and 0.89 fold, respectively, in the suspension (pH 7.35), as compared with 1 mM inorganic phosphate. However NH4Cl, lactic acid or hypoxanthine did not affect erythrocyte purine nucleotides.(ABSTRACT TRUNCATED AT 250 WORDS)
T Yamamoto; Y Moriwaki; S Takahashi; H Ishizashi; K Higashino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  26     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-04-06     Completed Date:  1995-04-06     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  504-8     Citation Subset:  IM; S    
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
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MeSH Terms
Adenosine Diphosphate / blood
Adenosine Monophosphate / blood
Ammonium Chloride / blood,  pharmacology
Erythrocytes / metabolism*
Exercise / physiology*
Guanosine Diphosphate / blood
Guanosine Triphosphate / blood
Hypoxanthines / blood,  pharmacology
Inosine Monophosphate / blood
Lactates / blood,  pharmacology
Lactic Acid
Muscles / physiology*
Phosphates / blood,  pharmacology
Purine Nucleotides / blood*
Reg. No./Substance:
0/Hypoxanthines; 0/Lactates; 0/Phosphates; 0/Purine Nucleotides; 12125-02-9/Ammonium Chloride; 131-99-7/Inosine Monophosphate; 146-91-8/Guanosine Diphosphate; 50-21-5/Lactic Acid; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 68-94-0/Hypoxanthine; 86-01-1/Guanosine Triphosphate

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