| Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects. | |
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MedLine Citation:
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PMID: 16896724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anabolic androgenic steroids (AAS) are doping agents that are mostly used for improvement of strength and muscle hypertrophy. In some sports, athletes reported that the intake of AAS is associated with a better recovery, a higher training load capacity and therefore an increase in physical and mental performances. The purpose of this study was to evaluate, the effect of multiple doses of AAS on different physiological parameters that could indirectly relate the physical state of athletes during a hard endurance training program. In a double blind settings, three groups (n = 9, 8 and 8) were orally administered placebo, testosterone undecanoate or 19-norandrostenedione, 12 times during 1 month. Serum biomarkers (creatine kinase, ASAT and urea), serum hormone profiles (testosterone, cortisol and LH) and urinary catecholamines (noradrenalin, adrenalin and dopamine) were evaluated during the treatment. Running performance was assessed before and after the intervention phase by means of a standardized treadmill test. None of the measured biochemical variables showed significant impact of AAS on physical stress level. Data from exercise testing on submaximal and maximal level did not reveal any performance differences between the three groups or their response to the treatment. In the present study, no effect of multiple oral doses of AAS on endurance performance or bioserum recovery markers was found. |
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Authors:
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Norbert Baume; Yorck Olaf Schumacher; Pierre-Edouard Sottas; Carlo Bagutti; Michel Cauderay; Patrice Mangin; Martial Saugy |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-08-03 |
Journal Detail:
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Title: European journal of applied physiology Volume: 98 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 329-40 Citation Subset: IM |
Affiliation:
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Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland. norbaume@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anabolic Agents / pharmacology* Androgens / pharmacology* Androstenedione / analogs & derivatives, pharmacology Biological Markers Catecholamines / urine Double-Blind Method Exercise Test Heart Rate / drug effects, physiology Hormones / blood Humans Hydrocortisone / blood Lactic Acid / blood Male Physical Endurance / drug effects* Physical Fitness / physiology Running / physiology Steroids / pharmacology* Stress, Psychological / blood*, urine Testosterone / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Androgens; 0/Biological Markers; 0/Catecholamines; 0/Hormones; 0/Steroids; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone; 58-22-0/Testosterone; 63-05-8/Androstenedione; 734-32-7/19-norandrostenedione |
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