Document Detail

Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects.
MedLine Citation:
PMID:  16896724     Owner:  NLM     Status:  MEDLINE    
Anabolic androgenic steroids (AAS) are doping agents that are mostly used for improvement of strength and muscle hypertrophy. In some sports, athletes reported that the intake of AAS is associated with a better recovery, a higher training load capacity and therefore an increase in physical and mental performances. The purpose of this study was to evaluate, the effect of multiple doses of AAS on different physiological parameters that could indirectly relate the physical state of athletes during a hard endurance training program. In a double blind settings, three groups (n = 9, 8 and 8) were orally administered placebo, testosterone undecanoate or 19-norandrostenedione, 12 times during 1 month. Serum biomarkers (creatine kinase, ASAT and urea), serum hormone profiles (testosterone, cortisol and LH) and urinary catecholamines (noradrenalin, adrenalin and dopamine) were evaluated during the treatment. Running performance was assessed before and after the intervention phase by means of a standardized treadmill test. None of the measured biochemical variables showed significant impact of AAS on physical stress level. Data from exercise testing on submaximal and maximal level did not reveal any performance differences between the three groups or their response to the treatment. In the present study, no effect of multiple oral doses of AAS on endurance performance or bioserum recovery markers was found.
Norbert Baume; Yorck Olaf Schumacher; Pierre-Edouard Sottas; Carlo Bagutti; Michel Cauderay; Patrice Mangin; Martial Saugy
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-08-03
Journal Detail:
Title:  European journal of applied physiology     Volume:  98     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  329-40     Citation Subset:  IM    
Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland.
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MeSH Terms
Anabolic Agents / pharmacology*
Androgens / pharmacology*
Androstenedione / analogs & derivatives,  pharmacology
Biological Markers
Catecholamines / urine
Double-Blind Method
Exercise Test
Heart Rate / drug effects,  physiology
Hormones / blood
Hydrocortisone / blood
Lactic Acid / blood
Physical Endurance / drug effects*
Physical Fitness / physiology
Running / physiology
Steroids / pharmacology*
Stress, Psychological / blood*,  urine
Testosterone / pharmacology
Reg. No./Substance:
0/Anabolic Agents; 0/Androgens; 0/Biological Markers; 0/Catecholamines; 0/Hormones; 0/Steroids; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone; 58-22-0/Testosterone; 63-05-8/Androstenedione; 734-32-7/19-norandrostenedione

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