Document Detail

Effect of mucolytic and bronchodilator aerosol therapy on airway resistance in mechanically ventilated patients.
MedLine Citation:
PMID:  3936867     Owner:  NLM     Status:  MEDLINE    
Nebulisation of a 10% solution of Mesna (Mistabron) in 10 postoperatively ventilated patients without preexisting pulmonary disease caused a significant increase in inspiratory resistance. This increase is effectively blocked by addition of a bronchodilator (i.e. Salbutamol) to the aerosol. No significant changes in airway resistance were observed in the 10 patients receiving salbutamol alone or isotonic saline. The expiratory resistance did not change suggesting that only the larger airways are involved in the constrictive effect of the drug. Although no patient showed clinical signs of bronchospasm, it is worth considering that even in patients without history of obstructive pulmonary disease nebulisation of Mesna should be performed in combination with a bronchodilator.
D F Zandstra; C P Stoutenbeek; D R Miranda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  11     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-26     Completed Date:  1986-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  316-8     Citation Subset:  IM    
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MeSH Terms
Airway Resistance / drug effects*
Albuterol / therapeutic use*
Bronchodilator Agents / therapeutic use
Expectorants / therapeutic use
Mercaptoethanol / analogs & derivatives*
Mesna / antagonists & inhibitors,  therapeutic use*
Postoperative Care
Respiration, Artificial*
Reg. No./Substance:
0/Aerosols; 0/Bronchodilator Agents; 0/Expectorants; 18559-94-9/Albuterol; 19767-45-4/Mesna; 60-24-2/Mercaptoethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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