Document Detail

Effect of mouthrinsing after toothbrushing with a fluoride dentifrice on human salivary fluoride levels.
MedLine Citation:
PMID:  1913767     Owner:  NLM     Status:  MEDLINE    
In a recent clinical trial of sodium monofluorophosphate dentifrices, oral rinsing habits were found to influence dental caries. Thus an oral fluoride clearance study has been undertaken which was designed to test a possible mechanism for the observed effects. Eight subjects brushed with one of the trial dentifrices and then rinsed using 1 of 8 procedures of varying thoroughness. The salivary fluoride concentration measured 5 min after dentifrice application decreased significantly with increasing rinse volume, rinse duration, and rinse frequency (p less than 0.01, analysis of variance). The area under the clearance curve determined over a further 3 h was significantly higher (300%; p less than 0.01) following use of the least thorough rinsing procedure (5 ml x 2 s once) as compared with the corresponding area under the clearance curve following the most thorough procedure (20 ml x 10 s twice). These findings indicate that rinsing habits may play an important role in the oral retention of fluoride from dentifrices which may, in turn, affect their clinical efficacy.
R M Duckworth; D T Knoop; K W Stephen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Caries research     Volume:  25     ISSN:  0008-6568     ISO Abbreviation:  Caries Res.     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-21     Completed Date:  1991-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0103374     Medline TA:  Caries Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  D; IM    
Unilever Dental Research, Port Sunlight Laboratory, Bebington, UK.
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MeSH Terms
Dental Caries / prevention & control
Dentifrices / therapeutic use*
Fluorides / analysis*,  pharmacokinetics,  therapeutic use
Mouthwashes / administration & dosage,  pharmacology*
Phosphates / therapeutic use
Saliva / chemistry*,  metabolism
Time Factors
Reg. No./Substance:
0/Dentifrices; 0/Fluorides; 0/Mouthwashes; 0/Phosphates; 15181-43-8/fluorophosphate; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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