Document Detail


Effect of motilin on the opossum upper gastrointestinal tract and sphincter of Oddi.
MedLine Citation:
PMID:  6624915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of motilin on myoelectric activity of the sphincter of Oddi (SO) and upper gastrointestinal tract in conscious opposums. In 17 animals, bipolar electrodes were implanted on the gastric antrum, SO, duodenum, and jejunum. Subsequent 8-h recordings reconfirmed our previous findings that SO spike burst rate changed with interdigestive cycles of the gastrointestinal migrating myoelectric complex (MMC), becoming maximal during passage of phase III activity through the duodenum. In eight animals, peak motilin levels were shown to occur concurrently with maximal SO spike burst rate and MMC phase III activity in the duodenum. Motilin infusion (0.3 and 0.9 micrograms X kg-1 X h-1), given for 30-60 min starting 10 min after duodenal phase III, elicited premature MMC activity that originated in the stomach. Maximal SO activity occurred coincident with passage of premature phase III activity through the duodenum. Pulse intravenous doses of motilin (25-1,600 ng/kg) generally caused an immediate increase in spike burst activity in the gastric antrum, duodenum, and SO that lasted 3-5 min and was often followed by a premature MMC, usually starting in the antrum and progressing through the duodenum and jejunum. Increases in SO spike burst rate also occurred concurrent with motilin-induced, premature duodenal phase III. Motilin given at 5-60% of the duodenal MMC cycle length elicited premature MMCs at 10-60% of the cycle, but no premature MMCs were elicited by any of the motilin doses at the 5% intervals.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
I Takahashi; R Honda; W J Dodds; S Sarna; J Toouli; Z Itoh; W Y Chey; W J Hogan; D Greiff; K Baker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  245     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G476-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ampulla of Vater / physiology*
Animals
Digestive System / drug effects
Digestive System Physiological Phenomena*
Dose-Response Relationship, Drug
Gastrointestinal Hormones / pharmacology*
Intestine, Small / physiology
Motilin / blood,  pharmacology*
Muscle Contraction / drug effects
Muscle, Smooth / physiology
Opossums
Sphincter of Oddi / drug effects,  physiology*
Stomach / physiology
Grant Support
ID/Acronym/Agency:
AM-30024/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones; 52906-92-0/Motilin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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