Document Detail

Effect of morphine on limb capacitance and resistance vessels.
MedLine Citation:
PMID:  7237924     Owner:  NLM     Status:  MEDLINE    
1. The actions of 15 mg of intravenous morphine on hand and forearm capacitance and resistance vessels were studied with venous occlusion plethysmography. 2. In contrast to a 5% increase in forearm venous volume, intravenous morphine caused a 26% decrease in hand venous volume. This hand venoconstriction was confirmed by finding an increase in hand venous tone. The effects of morphine on hand veins were attenuated by intraarterial phentolamine and blocked by intravenous naloxone. 3. Whereas morphine had no significant effect on forearm resistance vessels, it caused a 70% reduction in hand vascular resistance. 4. Intra-arterial morphine had no local action on hand capacitance or resistance vessels. 5. Though the contrasting actions of morphine on hand and forearm capacitance vessels resulted in no important change in limb venous capacitance, the large reduction of cutaneous vascular resistance may contribute to haemodynamic benefit in patients with pulmonary oedema.
R A Cohen; J D Coffman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  60     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
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MeSH Terms
Forearm / blood supply*
Hand / blood supply*
Morphine / pharmacology*
Regional Blood Flow / drug effects
Vascular Resistance / drug effects*
Veins / drug effects
Grant Support
5507 RR 05487-17/RR/NCRR NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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