| Effect of moricizine hydrochloride in reducing chronic high-frequency ventricular arrhythmia: results of a prospective, controlled trial. | |
| | |
MedLine Citation:
|
PMID: 6367416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The antiarrhythmic efficacy of moracizin HCl (Ethmozine), a new oral phenothiazine derivative, was evaluated in 20 patients with chronic high-frequency ventricular arrhythmia confirmed by multiple ambulatory electrocardiographic recordings. Comparison with 72 +/- 24 hours (+/- standard deviation) of ambulatory recordings on moracizin treatment (average dose 295 +/- 58 mg 3 times daily or 9.8 +/- 1.0 mg/kg/day) was made. Maximal treadmill exercise provocation of arrhythmia and echocardiographic studies to detect effects on left ventricular function were also compared. The group had an average of 378 +/- 97 ventricular premature beats (VPBs) per hour while receiving placebo, with a mean VPB grade of 3.4 +/- 1.1 (modified Lown). When the patients received moracizin HCl, VPB frequency was reduced 53% (p less than 0.01), to a mean VPB grade of 2.2 +/- 1.4 (p less than 0.05). Seventy percent of the patients (14 of 20) showed a reduction in VPB frequency that exceeded the maximal expected variation; in 3 the frequency did not change and in 3 it increased with moracizin HCl. Resting electrocardiographic changes consisted of modest prolongations of PR interval (0.03 second) and QRS duration (0.02 second); however, QT prolongation was not observed. Heart rate and blood pressure at rest and peak exercise, exercise-related arrhythmia, exercise durations and echocardiographic measures of left ventricular function were unchanged by moracizin HCl compared with placebo. Side effects of moracizin++ HCl at these dosages were minimal (diarrhea in 1 patient, dizziness in 1 and diaphoresis in 1), although 2 patients tested at higher dosages had sustained ventricular tachycardia that may have been related to moracizin HCl.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
S N Singh; R DiBianco; J S Gottdiener; R Ginsberg; R D Fletcher |
Related Documents
:
|
2417856 - The surdo-cardiac syndrome. 10090226 - Left ventricular ischemia due to coronary stenosis as an unexpected treatable cause of ... 18175856 - Relationship between electrocardiographic rr and qt interval variabilities and indices ... 7997556 - Trisomy 13 syndrome: prenatal us findings in a review of 33 cases. 2037816 - Evaluation of a newly devised three-lead holter recording during treadmill testing in t... 2311596 - Reduction of saliva immunoglobulin levels by swim training. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The American journal of cardiology Volume: 53 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1984 Mar |
Date Detail:
|
Created Date: 1984-04-13 Completed Date: 1984-04-13 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 745-50 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Anti-Arrhythmia Agents / adverse effects, therapeutic use* Arrhythmias, Cardiac / drug therapy* Chronic Disease Clinical Trials as Topic Echocardiography Electrocardiography Exercise Test Heart / physiopathology Humans Male Middle Aged Moricizine Phenothiazines / adverse effects, therapeutic use* Prospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 0/Phenothiazines; 31883-05-3/Moricizine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Randomized double-blind comparison of gallopamil and propranolol in stable angina pectoris.
Next Document: Effects of diuretic therapy in low-, normal- and high-renin isolated systolic systemic hypertension.