Document Detail


Effect of moricizine on heart rate variability in normal subjects.
MedLine Citation:
PMID:  7744539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of moricizine HCl, a type Ic anti-arrhythmic agent, on heart rate variability. Decreased heart rate variability is a risk factor for mortality in post-MI and other patient populations, and some antiarrhythmic drugs decrease heart rate variability. Normal volunteers (10 M, 11 F, age 19-39 years) received blinded placebo and moricizine HCl at 200 mg twice daily for 5 days. On day 4, a 24-h ECG was obtained, and time and frequency domain measures of heart rate variability based on normal-to-normal intervals were computed. Moricizine decreased both time and frequency domain measures of heart rate variability. Significant reductions were seen for SDNNIDX (the average S.D. for N-Ns for each 5-min interval in ms) and pNN50 (the proportion of successive N-N differences > 50 ms in percent) in the time domain, and very low (0.0033-0.04 Hz), low (0.04-0.15 Hz) and high (0.15-0.4 Hz) frequency power. Similar patterns of change in heart rate variability were seen when data for daytime and nighttime periods were analyzed separately. rMSSD (the root mean square successive difference of N-N intervals in ms), pNN50 and high frequency power are primarily indices of parasympathetic tone. SDNNIDX, and very low and low frequency power reflect both sympathetic and parasympathetic tone and longer term variability. Thus, moricizine decreases both vagal tone and longer term components of heart rate variability. This decrease produced by moricizine is similar to that reported with other type 1 antiarrhythmics.
Authors:
P K Stein; J N Rottman; T Kuru; R E Kleiger
Related Documents :
21584989 - Military morality transformed: weapons and soldiers on the nineteenth-century battlefield.
23703369 - Home-based circuit resistance training to overcome barriers to exercise for people with...
15907059 - A short duration of physical training benefits cardiovascular performance.
20725109 - Sex differences in linear and nonlinear heart rate variability during early recovery fr...
17402419 - Effect of repeated exercise and recovery on heart rate variability in elite trotting ho...
15120749 - Influence of sympathetic autonomic arousal on cortical arousal: implications for a ther...
21700759 - Use of non-invasive haemodynamic measurements to detect treatment response in precapill...
15085209 - Surface electromyographic activity of the abdominal muscles during pelvic-tilt and abdo...
23621999 - Exercise-induced bronchoconstriction.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  48     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-09     Completed Date:  1995-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Jewish Hospital of St. Louis, MO 63110, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Circadian Rhythm / physiology
Electrocardiography*
Female
Heart Rate / drug effects*,  physiology*
Humans
Male
Moricizine / pharmacology*
Risk Factors
Time Factors
Chemical
Reg. No./Substance:
31883-05-3/Moricizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  ST segment reelevation after acute myocardial infarction: marked differences in the electrocardiogra...
Next Document:  QTc interval prolongation during infusion with dipyridamole or adenosine.