Document Detail


Effect of monosodium glutamate on retinal vessel development and permeability in rats.
MedLine Citation:
PMID:  7251307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monosodium glutamate (MSG) administered to neonatal rats on postnatal days 1 to 10 caused a generalized degeneration of the inner retinal layers. MSG administered only on postnatal days 8, 9, 10, and/or 11 caused a retinopathy limited to more peripheral retinal areas corresponding to currently existing regions of immature retinal vessels. Ink-injected retinal vessel studies showed a delay in development of the retinal vessel network but no alterations in vessel patency. Fluorescence microscopic examination of freeze-dried tissues revealed to abnormalities of the blood-retinal barriers to sodium fluorescein. We conclude, as demonstrated by these methods, that MSG retards development of the retinal vessels but does not affect development of the blood-retinal barriers. The retinotoxic effect of MSG apparently results from a mechanism(s) other than a breakdown of the blood-retinal barrier.
Authors:
R W Bellhorn; D A Lipman; J Confino; M S Burns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  21     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Glutamates / adverse effects*
Permeability
Rats
Retinal Degeneration / chemically induced*,  pathology
Retinal Vessels / drug effects*,  growth & development
Sodium Glutamate / adverse effects*,  pharmacology
Grant Support
ID/Acronym/Agency:
EY 01103/EY/NEI NIH HHS; EY 02038/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Glutamates; 142-47-2/Sodium Glutamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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