Document Detail

Effect of monocytopenia on trauma-induced atherosclerotic lesions in the rabbit ear artery.
MedLine Citation:
PMID:  3396669     Owner:  NLM     Status:  MEDLINE    
In a trauma model of atherosclerosis (repeated mechanical injury of the rabbit ear artery), rabbits were pretreated either with etoposid (inducing a monocytopenia) or with prednisolone (inhibiting monocyte function) to investigate the role of monocytes in traumatically induced plaque formation. Three weeks after the last injury the arteries were carefully examined. While a profound monocytopenia during the period of injuries did not at all influence the size of the plaque formation, this was almost completely inhibited in the prednisolone-treated rabbits. Obviously, the effect of prednisolone must be attributed to other pharmacological properties. Monocytes appear to be of less importance in purely trauma atherosclerosis models.
R Voss; I R Mueller; F R Matthias
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and molecular pathology     Volume:  49     ISSN:  0014-4800     ISO Abbreviation:  Exp. Mol. Pathol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-02     Completed Date:  1988-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370711     Medline TA:  Exp Mol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-86     Citation Subset:  IM    
Department of Internal Medicine, Justus-Liebig-University, Giessen, Federal Republic of Germany.
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MeSH Terms
Arteries / pathology*
Arteriosclerosis / blood*,  pathology
Disease Models, Animal
Etoposide / pharmacology
Leukocyte Count
Leukopenia / pathology
Monocytes / physiology*
Prednisolone / pharmacology
Reg. No./Substance:
33419-42-0/Etoposide; 50-24-8/Prednisolone

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