| Effect of monocytopenia on trauma-induced atherosclerotic lesions in the rabbit ear artery. | |
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MedLine Citation:
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PMID: 3396669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a trauma model of atherosclerosis (repeated mechanical injury of the rabbit ear artery), rabbits were pretreated either with etoposid (inducing a monocytopenia) or with prednisolone (inhibiting monocyte function) to investigate the role of monocytes in traumatically induced plaque formation. Three weeks after the last injury the arteries were carefully examined. While a profound monocytopenia during the period of injuries did not at all influence the size of the plaque formation, this was almost completely inhibited in the prednisolone-treated rabbits. Obviously, the effect of prednisolone must be attributed to other pharmacological properties. Monocytes appear to be of less importance in purely trauma atherosclerosis models. |
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Authors:
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R Voss; I R Mueller; F R Matthias |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental and molecular pathology Volume: 49 ISSN: 0014-4800 ISO Abbreviation: Exp. Mol. Pathol. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-02 Completed Date: 1988-09-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 75-86 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Justus-Liebig-University, Giessen, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / pathology* Arteriosclerosis / blood*, pathology Disease Models, Animal Etoposide / pharmacology Female Hematocrit Leukocyte Count Leukopenia / pathology Monocytes / physiology* Prednisolone / pharmacology Rabbits |
| Chemical | |
Reg. No./Substance:
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33419-42-0/Etoposide; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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