Document Detail

Effect of monocrotophos on mono amine oxidase activity in albino rats.
MedLine Citation:
PMID:  1799376     Owner:  NLM     Status:  MEDLINE    
Monocrotophos inhibited monoamine oxidase (MAO) activity both in vitro and in vivo in liver, kidney and brain areas of albino rats. In vitro effect was more pronounced than the in vivo effect. During in vivo daily treatment with sublethal doses of Monocrotophos, the MAO activity was significantly inhibited after 1h to 7 days of treatments. Later recovery of inhibition was noticed which might be attributed to the enhanced absorption of Monocrotophos to protein and fat bodies or enhanced metabolic dispositional mechanisms. Brain areas exhibit varied responses to Monocrotophos toxicity.
K V Swamy; T Srinivas; P M Mohan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry international     Volume:  24     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1992-04-13     Completed Date:  1992-04-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  785-92     Citation Subset:  IM    
Department of Zoology, Sri Venkateswara University, Tirupati, India.
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MeSH Terms
Brain / drug effects,  enzymology
Kidney / drug effects,  enzymology
Liver / drug effects,  enzymology
Monoamine Oxidase / drug effects*,  metabolism
Monoamine Oxidase Inhibitors / pharmacology
Monocrotophos / pharmacology*
Rats, Inbred Strains
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 6923-22-4/Monocrotophos; EC Oxidase

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