Document Detail

Effect of monoamine oxidase gene knockout on dopamine metabolism in mouse brain structures.
MedLine Citation:
PMID:  15452609     Owner:  NLM     Status:  MEDLINE    
Experiments were performed on knockout Tg8 mice lacking monoamine oxidase A gene that plays a major role in dopamine catabolism. The study by the method of high-performance liquid chromatography revealed considerable regional differences in the contents of dopamine and its metabolite dihydroxyphenylacetic acid in brain structures of these animals. Tg8 mice differed from the parent C3H/HeJ strain by low level of dihydroxyphenylacetic acid in the striatum, midbrain, hypothalamus, and hippocampus and high concentration of dopamine in the striatum. No differences were revealed in the contents of dopamine and dihydroxyphenylacetic acid in the frontal cortex and amygdala. The 2.4-4.8-fold decrease in the content of dihydroxyphenylacetic acid in various brain structures was not accompanied by changes in dopamine concentration. These data reflect the effective compensation for deficiency of dopamine metabolism. Our results suggest that monoamine oxidases A and B and catechol-O-methyltransferase play different roles in dopamine metabolism in various brain structures.
N K Popova; M A Gilinskii; T G Amstislavskaya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  137     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-09-28     Completed Date:  2005-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  382-4     Citation Subset:  IM    
Laboratory for Neurogenomics of Behavior, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / chemistry,  metabolism
Brain / anatomy & histology*,  metabolism*
Brain Chemistry
Dopamine / chemistry*,  metabolism
Mice, Inbred Strains
Mice, Knockout
Monoamine Oxidase / genetics*,  metabolism*
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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