Document Detail

Effect of moniliformin on myocardial contractility in rats.
MedLine Citation:
PMID:  1764219     Owner:  NLM     Status:  MEDLINE    
The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10(-7) mol/liter in isolated heart decreased myocardial contractile force by 52 +/- 17%. Intravenous injection of moniliformin at 1/6 and 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased +/- LV dP/dt max by 52 +/- 6%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease.
L L Fan; J Li; L H Sun
Related Documents :
8022049 - Comparison of the effects of dobutamine and isoproterenol in ischemic hearts by phospho...
24256139 - Reperfusion after 4·5 hours reduces infarct growth and improves clinical outcomes.
2422459 - Defibrotide, an antithrombotic substance that preserves postsynaptic alpha- and beta-ad...
14618229 - Acute right ventricular failure--from pathophysiology to new treatments.
17255859 - Levosimendan improves right ventriculovascular coupling in a porcine model of right ven...
10422929 - Contractility in humans after coronary artery surgery.
9725159 - Effects of left atrial dilatation on the endocardial atrial defibrillation threshold: a...
15217909 - Right ventricular myocardium derives from the anterior heart field.
18365599 - Acute myocardial infarction and ascending aortic aneurysm in a child with behçet's dis...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biomedical and environmental sciences : BES     Volume:  4     ISSN:  0895-3988     ISO Abbreviation:  Biomed. Environ. Sci.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-02-18     Completed Date:  1992-02-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8909524     Medline TA:  Biomed Environ Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-4     Citation Subset:  IM    
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cyclobutanes / toxicity*
Heart / drug effects
Hemodynamics / drug effects
Mycotoxins / toxicity*
Myocardial Contraction / drug effects*
Rats, Inbred Strains
Reg. No./Substance:
0/Cyclobutanes; 0/Mycotoxins; 31876-38-7/moniliformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Subchronic oral toxicity of pyridostigmine bromide in rats.
Next Document:  The energy expenditure and nutritional status of college students. I. The energy cost and the total ...