Document Detail

Effect of moniliformin on myocardial contractility in rats.
MedLine Citation:
PMID:  1764219     Owner:  NLM     Status:  MEDLINE    
The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10(-7) mol/liter in isolated heart decreased myocardial contractile force by 52 +/- 17%. Intravenous injection of moniliformin at 1/6 and 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased +/- LV dP/dt max by 52 +/- 6%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease.
L L Fan; J Li; L H Sun
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biomedical and environmental sciences : BES     Volume:  4     ISSN:  0895-3988     ISO Abbreviation:  Biomed. Environ. Sci.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-02-18     Completed Date:  1992-02-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8909524     Medline TA:  Biomed Environ Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-4     Citation Subset:  IM    
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
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MeSH Terms
Cyclobutanes / toxicity*
Heart / drug effects
Hemodynamics / drug effects
Mycotoxins / toxicity*
Myocardial Contraction / drug effects*
Rats, Inbred Strains
Reg. No./Substance:
0/Cyclobutanes; 0/Mycotoxins; 31876-38-7/moniliformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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