| Effect of mometasone furoate (MF)/formoterol fumarate (F) combination (MF/F) on late-phase responses in allergen-challenged Brown Norway rats. | |
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MedLine Citation:
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PMID: 20937404 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Mometasone furoate (MF)/formoterol fumarate (F) combination is a new inhaIed corticosteroid/long-acting β(2)-adrenergic agonist (ICS/LABA). The purpose of this study was to evaluate the effects of different dose combinations of MF/F on a variety of late-phase responses to aerosolized antigen challenge in ovalbumin sensitized Brown Norway rats. Late-phase responses were assessed by reductions in lung function, measured by forced vital capacity (FVC) and increased numbers of inflammatory cells and pro-inflammatory cytokines in the bronchoalveolar lavage (BAL) fluid of ovalbumin challenged rats. Intratracheal administration of MF/F 5 h before aerosolized ovalbumin challenge inhibited the increase in inflammatory cells, including eosinophils and levels of interleukin (IL)-4, IL-5, IL-13 and tumour necrosis factor-α (TNF-α) appearing in the bronchoalveolar lavage fluid 24 h after the antigen challenge. The combination index for inhibition of both inflammatory cells and cytokines was consistently <1 suggesting a synergistic interaction between MF and F. Intratracheal MF/F given 24 h after the aerosolized ovalbumin challenge reversed the reduction in FVC with statistically significant effects seen over a 24 h period after drug whereas MF and F alone reversed the antigen-induced reduction in FVC at selected times only. At 5 h after drug administration, when both MF and F were partially active, the combination index for MF/F was <1 suggesting a synergistic interaction between MF and F for reversal of the lung function. These results demonstrate that MF/F combination inhibits a variety of late-phase responses induced by allergen challenge and it is likely that MF/F will have a significant benefit in clinical asthma to suppress lung inflammation and improve lung function. |
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Authors:
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Richard W Chapman; Aidan K Curran; Aileen House; Jennifer Richard; Brian Salisbury; John C Hunter; John C Anthes; Jonathan E Phillips |
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Publication Detail:
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Type: Journal Article Date: 2010-10-13 |
Journal Detail:
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Title: Pulmonary pharmacology & therapeutics Volume: 24 ISSN: 1522-9629 ISO Abbreviation: Pulm Pharmacol Ther Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9715279 Medline TA: Pulm Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 67-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Bone, Respiratory, Immunology and Dermatology, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033-0539, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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